From genomics to metabolomics, moving toward an integrated strategy for the discovery of fungal secondary metabolites

T Hautbergue, EL Jamin, L Debrauwer, O Puel… - Natural Product …, 2018 - pubs.rsc.org
Fungal secondary metabolites are defined by bioactive properties that ensure adaptation of
the fungus to its environment. Although some of these natural products are promising …

Unlocking fungal cryptic natural products

YM Chiang, KH Lee, JF Sanchez… - Natural product …, 2009 - journals.sagepub.com
Recent published sequencing of fungal genomes has revealed that these microorganisms
have a surprisingly large number of secondary metabolite pathways that can serve as …

Fungal identification using molecular tools: a primer for the natural products research community

HA Raja, AN Miller, CJ Pearce… - Journal of natural …, 2017 - ACS Publications
Fungi are morphologically, ecologically, metabolically, and phylogenetically diverse. They
are known to produce numerous bioactive molecules, which makes them very useful for …

Fungal secondary metabolites in food and pharmaceuticals in the era of multi-omics

A Shankar, KK Sharma - Applied Microbiology and Biotechnology, 2022 - Springer
Fungi produce several bioactive metabolites, pigments, dyes, antioxidants, polysaccharides,
and industrial enzymes. Fungal products are also the primary sources of functional food and …

Biologically active secondary metabolites from the fungi

GF Bills, JB Gloer - Microbiology spectrum, 2016 - Am Soc Microbiol
Many Fungi have a well-developed secondary metabolism. The diversity of fungal species
and the diversification of biosynthetic gene clusters underscores a nearly limitless potential …

Fungal secondary metabolism: regulation, function and drug discovery

NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …

Recent developments in metabolomics studies of endophytic fungi

K Nagarajan, B Ibrahim, A Ahmad Bawadikji, JW Lim… - Journal of Fungi, 2021 - mdpi.com
Endophytic fungi are microorganisms that colonize living plants' tissues without causing any
harm. They are known as a natural source of bioactive metabolites with diverse …

Scaffold diversity of fungal metabolites

M González-Medina, JR Owen, T El-Elimat… - Frontiers in …, 2017 - frontiersin.org
Many drug discovery projects rely on commercial compounds to discover active leads.
However, current commercial libraries, with mostly synthetic compounds, access a small …

In vivo and in vitro production options for fungal secondary metabolites

P Schneider, M Misiek, D Hoffmeister - Molecular Pharmaceutics, 2008 - ACS Publications
Microbial natural products, among them a vast diversity of fungal origin, represent a major
source for new drug candidates. Focusing on fungal metabolites, our review covers recent …

[HTML][HTML] Development of fungal cell factories for the production of secondary metabolites: Linking genomics and metabolism

JC Nielsen, J Nielsen - Synthetic and Systems Biotechnology, 2017 - Elsevier
The genomic era has revolutionized research on secondary metabolites and bioinformatics
methods have in recent years revived the antibiotic discovery process after decades with …