How do animal cells assemble into tissues and organs? A diverse array of tissue structures
and shapes can be formed by organizing groups of cells into different polarized …

The asymmetric polarization of cells allows specialized functions to be performed at discrete
subcellular locales. Spatiotemporal coordination of polarization between groups of cells …

Cell polarity is fundamental for the architecture and function of epithelial tissues. Epithelial
polarization requires the intervention of several fundamental cell processes, whose …

Cells exhibit morphological and molecular asymmetries that are broadly categorized as cell
polarity. The cell polarity established in early embryos prefigures the macroscopic …

Abstract Establishment of Planar Cell Polarity (PCP) in epithelia, in the plane of an
epithelium, is an important feature of the development and homeostasis of most organs …

Cells are highly complex and orderly machines, with defined shapes and a startling variety
of internal organizations. Complex geometry is a feature of both free-living unicellular …

Cell packing—the spatial arrangement of cells—determines the shapes of organs. Recently,
investigations of organ development in a variety of model organisms have uncovered …

One of the major challenges in biology is to explain how complex tissues and organs arise
from the collective action of individual polarized cells. The best-studied model of this process …

Epithelial cells comprise the foundation for the majority of organs in the mammalian body,
and are the source of approximately 90% of all human cancers. Characteristically, epithelial …

Cell polarity is defined as asymmetry in cell shape, protein distributions and cell functions. It
is characteristic of single-cell organisms, including yeast and bacteria, and cells in tissues of …