The field of nitric oxide (NO) biomedical research started in the 1970s with the observations
that the chemically unstable gas, NO, could activate cytosolic guanylate cyclase to stimulate …

Nitric oxide (NO) is a pivotal signaling messenger in the cardiovascular system. NO
participates in regulatory functions including control of hemostasis, fibrinolysis, platelet and …

Nitric oxide (NO) is a gaseous lipophilic free radical cellular messenger generated by three
distinct isoforms of nitric oxide synthases (NOS), neuronal (nNOS), inducible (iNOS) and …

Nitric oxide (NO) is a ubiquitous, naturally occurring molecule found in a variety of cell types
and organ systems. In the cardiovascular system, NO is an important determinant of basal …

Nitric oxide (NO) is one of the critical components of the vasculature, regulating key
signaling pathways in health. In macrovessels, NO functions to suppress cell inflammation …

In retrospect, basic research in the fields of NO and cyclic GMP during thev past two
decades appears to have followed a logical course beginning with the findings that NO and …

Nitric oxide (NO) is a relative newcomer to pharmacology, as the paper which initiated the
field was published only 25 years ago. Nevertheless its impact is such that to date more than …

Nitric oxide (NO) is a structurally simple, highly versatile molecule that was originally
discovered over 30 years ago as an endothelium-derived relaxing factor. In addition to its …

As the first discovered gaseous signaling molecule, nitric oxide (NO) affects a number of
cellular processes, including those involving vascular cells. This brief review summarizes …

Fifteen years after its discovery, NO has fully reached an established position in physiology,
medicine and therapeutics. It is difficult to find a biological function or a pathological …