Intracellular detection of virus infections is a critical component of innate immunity carried
out by molecules known as pathogen recognition receptors (PRRs). Activation of PRRs by …

Initiating the immune response to invading pathogens, the innate immune system is
constituted of immune receptors (pattern recognition receptors, PRR) that sense microbe …

The innate immune system initially recognizes RNA virus infection and evokes antiviral
responses by producing type I interferons (IFNs). Toll-like receptors (TLRs) and cytoplasmic …

RIG-I is essential for host defense against viral pathogens, as it triggers the release of type I
interferons upon encounter with viral RNA molecules. In this study, we show that RIG-I is …

ABSTRACT RIG-I is an intracellular RNA virus sensor that mediates a signaling pathway that
triggers the alpha/beta interferon (IFN-α/β) immune defenses. However, the mechanism for …

The current dogma of RNA-mediated innate immunity is that sensing of immunostimulatory
RNA ligands is sufficient for the activation of intracellular sensors and induction of interferon …

The innate immune system responds within minutes of infection to produce type I interferons
and pro-inflammatory cytokines. Interferons induce the synthesis of cell proteins with …

The innate immune system is our first line of defense against viral pathogens. Host cell
pattern recognition receptors sense viral components and initiate immune signaling …

The RIG-I–like receptors (RLRs) retinoic acid–inducible gene I protein (RIG-I) and
melanoma differentiation–associated protein 5 (MDA5) are cytosolic pattern recognition …

RIG-I-like receptors (RLRs: RIG-I, MDA5 and LGP2) play a major role in the innate immune
response against viral infections and detect patterns on viral RNA molecules that are …