[HTML][HTML] Therapeutic opportunities in inflammatory bowel disease: mechanistic dissection of host-microbiome relationships

DR Plichta, DB Graham, S Subramanian, RJ Xavier - Cell, 2019 - cell.com
The current understanding of inflammatory bowel disease (IBD) pathogenesis implicates a
complex interaction between host genetics, host immunity, microbiome, and environmental …

Inflammatory bowel diseases (IBD) and the microbiome—searching the crime scene for clues

M Lee, EB Chang - Gastroenterology, 2021 - Elsevier
Inflammatory bowel diseases (IBD) develop via convergence of environmental, microbial,
immunological, and genetic factors. Alterations in the gut microbiota have been associated …

The intestinal microbiome, barrier function, and immune system in inflammatory bowel disease: a tripartite pathophysiological circuit with implications for new …

SM Vindigni, TL Zisman, DL Suskind… - Therapeutic …, 2016 - journals.sagepub.com
We discuss the tripartite pathophysiological circuit of inflammatory bowel disease (IBD),
involving the intestinal microbiota, barrier function, and immune system. Dysfunction in each …

Inflammatory bowel disease pathogenesis: where are we?

C Fiocchi - Journal of gastroenterology and hepatology, 2015 - Wiley Online Library
Inflammatory bowel disease (IBD) is presently one of the most investigated human
disorders. Expansion of knowledge of its pathophysiology has helped in developing novel …

[HTML][HTML] Inflammatory bowel disease as a model for translating the microbiome

C Huttenhower, AD Kostic, RJ Xavier - Immunity, 2014 - cell.com
The inflammatory bowel diseases (IBDs) are among the most closely studied chronic
inflammatory disorders that involve environmental, host genetic, and commensal microbial …

Inflammatory bowel disease: exploring gut pathophysiology for novel therapeutic targets

V Yadav, F Varum, R Bravo, E Furrer, D Bojic… - Translational …, 2016 - Elsevier
Ulcerative colitis and Crohn's disease are the 2 major phenotypes of inflammatory bowel
disease (IBD), which are influenced by a complex interplay of immunological and genetic …

Genetic factors and the intestinal microbiome guide development of microbe-based therapies for inflammatory bowel diseases

LJ Cohen, JH Cho, D Gevers, H Chu - Gastroenterology, 2019 - Elsevier
The intestinal microbiota is a dynamic community of bacteria, fungi, and viruses that
mediates mucosal homeostasis and physiology. Imbalances in the microbiome and aberrant …

Pathway paradigms revealed from the genetics of inflammatory bowel disease

DB Graham, RJ Xavier - Nature, 2020 - nature.com
Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and
amplified by the confluence of multiple genetic and environmental variables that perturb the …

Cytokine networks and T-cell subsets in inflammatory bowel diseases

ML Chen, MS Sundrud - Inflammatory bowel diseases, 2016 - academic.oup.com
Pathogenesis of the inflammatory bowel diseases (IBDs), such as ulcerative colitis (UC) and
Crohn's disease (CD), involve proinflammatory changes within the microbiota, chronic …

A comprehensive review and update on the pathogenesis of inflammatory bowel disease

Q Guan - Journal of immunology research, 2019 - Wiley Online Library
Inflammatory bowel disease (IBD) is a chronic and life‐threating inflammatory disease of
gastroenteric tissue characterized by episodes of intestinal inflammation. The pathogenesis …