The induction of mouse skin papillomas by initiation-promotion protocols is associated with
aberrant expression of epithelial markers in the tumor mass. Similarly, initiation of mouse …

The mouse skin multistage model of carcinogenesis is an ideal system in which to study
questions related to the timing of oncogene activation and inactivation of tumor suppressor …

Objective: Previously we have shown that a malignant mouse keratinocyte cell line, 10Gy5,
has elevated AP-1 transactivation and reduced JunB protein levels compared to its parental …

Background: Previous studies demonstrated a functional involvement of the AP‐1
transcription factor in HPV‐induced cervical carcinogenesis. Here, we aimed to obtain …

We have stably expressed a trans-activation suppressing deletion mutant of the human c-jun
gene (TAM-67) in the malignant mouse epidermal cell lines 10Gy5 and PDV. Expression of …

The transcription factor AP‐1 represents a central key element in the expression of human
pathogenic papillomaviruses (HPV). We here propose a novel role for AP‐1 as an essential …

Tumor promoters may bring about events that lead to neoplastic transformation by inducing
specific promotion-relevant effector genes. Functional activation of the transacting …

We demonstrated previously that c‐Jun, JunB and c‐Fos RNA were dysregulated in
metastatic melanoma cells compared with normal human melanocytes. The purpose of this …

Neoplastic transformation and transcriptional activation by activator protein‐1 (AP‐1)
complex are stimulated by tumor‐promoting agents in promotion‐sensitive (P+) but not …

Activation of the transcription factor AP-1 (activator protein-1) is required for tumor promotion
and maintenance of malignant phenotype. A number of AP-1-regulated genes that play a …