Dominant-negative c-Jun (TAM67) target genes: HMGA1 is required for tumor promoter-induced transformation

A Dhar, J Hu, R Reeves, L Resar, NH Colburn - Oncogene, 2004 - nature.com
Activation of the transcription factor AP-1 (activator protein-1) is required for tumor promotion
and maintenance of malignant phenotype. A number of AP-1-regulated genes that play a …

[HTML][HTML] Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-κB

S Mathas, M Hinz, I Anagnostopoulos… - The EMBO …, 2002 - embopress.org
Aberrantly expressed c‐Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate
proliferation and synergize with NF‐κB | The EMBO Journal Skip to Article Content Skip to …

Suppression of AP1 transcription factor function in keratinocyte suppresses differentiation

B Han, EA Rorke, G Adhikary, YC Chew, W Xu… - PLoS …, 2012 - journals.plos.org
Our previous study shows that inhibiting activator protein one (AP1) transcription factor
function in murine epidermis, using dominant-negative c-jun (TAM67), increases cell …

Overexpression of JunB in undifferentiated malignant rat oral keratinocytes enhances the malignant phenotype in vitro without altering cellular differentiation

CM Robinson, SS Prime, S Huntley… - … journal of cancer, 2001 - Wiley Online Library
Our study examined the expression of AP‐1 family members in keratinocytes derived from
the rat‐4NQO model of oral carcinogenesis in which extremes of epithelial differentiation …

Gene regulation and genetic susceptibility to neoplastic transformation: AP-1 and p80 expression in JB6 cells.

LR Bernstein, ET Ben-Ari, SL Simek… - Environmental Health …, 1991 - ehp.niehs.nih.gov
The mouse epidermal JB6 cell system consists of clonal genetic variants that are sensitive
(P+) or resistant (P-) to the promotion of neoplastic transformation by phorbol esters and …

Constitutive activation of transcription factor AP‐1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP‐1 activity in HeLa cells by …

BK Prusty, BC Das - International journal of cancer, 2005 - Wiley Online Library
The transcription factor AP‐1 plays a central role in the transcriptional regulation of specific
types of high‐risk human papillomaviruses (HPVs) such as HPV16 and HPV18, which are …

Dominant-negative transcription factor AP-2 augments SB-2 melanoma tumor growth in vivo

JE Gershenwald, W Sumner, T Calderone, Z Wang… - Oncogene, 2001 - nature.com
We have previously demonstrated that the transition of melanoma to the metastatic
phenotype is associated with a loss of expression of the transcription factor AP-2. To further …

Activation and inhibition of the AP‐1 complex in human breast cancer cells

TK Chen, LM Smith, DK Gebhardt… - … in cooperation with …, 1996 - Wiley Online Library
We have studied the expression and activity of the jun and fos families of transcription
factors in a panel of human breast cancer cells. Numerous breast‐cancer cell lines showed …

Activator protein-1 activity regulates epithelial tumor cell identity

MJ Gerdes, M Myakishev, NA Frost, V Rishi, J Moitra… - Cancer research, 2006 - AACR
To examine the consequences of inhibiting activator protein-1 (AP-1) transcription factors in
skin, transgenic mice were generated, which use the tetracycline system to conditionally …

Retinoic acid‐induced AP‐1 transcriptional activity regulates B16 mouse melanoma growth inhibition and differentiation

Y Huang, G Boskovic, RM Niles - Journal of cellular physiology, 2003 - Wiley Online Library
Retinoic acid (RA) inhibits growth and induces differentiation of B16 mouse melanoma cells.
These effects are accompanied by a large increase in PKCα mRNA and protein levels and …