Mitogen-activated protein (MAP) kinase, extracellular-signal-regulated kinases (ERKs) play
an important role in activating AP-1-dependent transcription. Studies using the JB6 mouse …

The effects of UVB irradiation on transcription factor activator protein-1 (AP-1) DNA binding
and AP-1 transactivation were studied in a human keratinocyte cell line, HaCaT. UVB …

Bovine papillomavirus transgenic mice develop skin tumors arising from dermal fibroblasts
in a process comprised of three distinctive stages: mild and aggressive fibromatoses, and …

The molecular changes associated with the transition of melanoma cells from radial growth
phase (RGP) to vertical growth phase [(VGP), metastatic phenotype] are not very well …

Abstract The activating protein-1 (AP-1) transcription factor transduces growth signals
through signal transduction pathways to the nucleus, leading to the expression of genes …

The proto-oncogenes jun and fos are members of the AP-1 family of transcription factors,
which activate transcription of target genes via the tetradecanoyl phorbol acetate response …

Growth factors activate cascades of intracellular events, some of which result in altered gene
expression. A series of recent discoveries have highlighted the role of the transcription factor …

AP-1-associated factor 1 (AF-1), is a novel protein complex that dramatically enhances the
assembly of JunD-containing dimers onto AP-1 consensus sites. We describe the partial …

Genetically modified mice have provided important insights into the biological functions of
the dimeric transcription factor complex AP-1. Extensive analyses of mice and cells with …

Normal human epidermal keratinocytes are induced to undergo terminal differentiation
when disaggregated and placed in suspension: commitment occurs at about 5 h and overt …