The hypothesis that cytochrome P450 3A (CYP3A) and P-glycoprotein (P-gp) played
complementary roles in drug absorption and disposition was first proposed 15 years ago. 1 …

Introduction: Transporters and enzymes play an important role in absorption, distribution,
clearance and elimination of drugs. Areas covered: This review provides an overview of the …

In recent years, the functional interplay between drug-metabolizing enzymes (DMEs) and
drug transporters (DTs) in drug absorption and disposition, as well as the complex drug …

Two decades ago the importance of transporter− enzyme interplay and its effects on drug
bioavailability and hepatic disposition were first recognized. Here we review the history of …

As discussed in earlier articles, predictions of in vivo drug-drug interactions from in vitro
studies is a subject of high interest with obvious therapeutic as well as economic benefits …

Both metabolizing enzymes and drug transporters play important roles in modulating drug
absorption, distribution, metabolism and elimination. Acting alone or in concert with each …

The interaction between drug-metabolising enzymes and active transporters is an emerging
concept in pharmacokinetics. In the gut mucosa, P-glycoprotein and cytochrome P450 (CYP) …

The ability to predict hepatic metabolic clearance is a key component in the design and
selection of small molecule drug candidates within the pharmaceutical industry. The …

Introduction: It is becoming increasingly evident that transporters play an important role in
the absorption, distribution and elimination of many drugs. Different approaches have been …

Background: Hepatic transporters, including efflux transporters and uptake transporters,
have been recognized to play an important role in the disposition of various drugs. These …