The COVID-19 pandemic is a major threat to global health for which there are only limited
medical countermeasures, and we lack a thorough understanding of mechanisms of …

The ongoing pandemic of coronavirus disease 2019 (COVID-19), which is caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major threat to global health …

Potent neutralizing monoclonal antibodies are one of the few agents currently available to
treat COVID-19. SARS-CoV-2 variants of concern (VOCs) that carry multiple mutations in the …

Development of effective therapeutics for mitigating the COVID-19 pandemic is a pressing
global need. Neutralizing antibodies are known to be effective antivirals, as they can be …

Saturation suppressor mutagenesis was used to generate thermostable mutants of the
SARS-CoV-2 spike receptor-binding domain (RBD). A triple mutant with an increase in …

Structural principles underlying the composition and synergistic mechanisms of protective
monoclonal antibody cocktails are poorly defined. Here, we exploited antibody cooperativity …

The SARS-CoV-2 viral spike (S) protein mediates attachment and entry into host cells and is
a major target of vaccine and drug design. Potent SARS-CoV-2 neutralizing antibodies …

Immediately from the outset of the COVID-19 pandemic, researchers from diverse
biomedical and biological disciplines have united to study the novel pandemic virus, SARS …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads worldwide and
leads to an unprecedented medical burden and lives lost. Neutralizing antibodies provide …

Neutralizing antibodies represent a valuable therapeutic approach to countermeasure the
current COVID-19 pandemic. Emergence of SARS-CoV-2 variants emphasizes the notion …