Behavior of IL-6 and Its Soluble Receptor Complex during Different Waves of the COVID-19 Pandemic

G Di Spigna, B Covelli, M Vargas, R Di Caprio… - 2024 - preprints.org
In late December 2019 a novel RNA beta-coronavirus was recognized as the causative
agent of previously pneumonia cases of unknown origin. The virus was successively named …

[PDF][PDF] Drastically elevated levels of Interleukin-6 and its soluble receptor complex in COVID-19 patients with acute respiratory distress

G Di Spigna, DS Cernia, M Vargas… - Clin Med …, 2020 - siriusstore.com
In December 2019 a novel RNA beta-corona virus, highly contagious, was recognized to be
the cause of previously pneumonia cases of unknown origin. The virus is phylo-genetically …

[HTML][HTML] Identification of IL-6 signalling components as predictors of severity and outcome in COVID-19

MÁ Rodríguez-Hernández, D Carneros… - Frontiers in …, 2022 - frontiersin.org
IL-6 is one of the major mediators of the hyper-inflammatory responses with complex
biological functions as it can signal via different modes of action. IL-6 by classical signalling …

[HTML][HTML] What do we know about IL-6 in COVID-19 so far?

J Jiang, J Wang, L Yao, S Lai, X Zhang - Biophysics Reports, 2021 - ncbi.nlm.nih.gov
Abstract Interleukin 6 (IL-6) is a cytokine with dual functions of pro-inflammation and anti-
inflammation. It is mainly produced by mononuclear macrophages, Th2 cells, vascular …

[HTML][HTML] Multifactorial expression of IL‑6 with update on COVID‑19 and the therapeutic strategies of its blockade

E Niculet, V Chioncel, AM Elisei… - Experimental and …, 2021 - spandidos-publications.com
Abstract Interleukin 6 (IL‑6), a cytokine produced by various cells of the human body
(macrophages, lymphocytes, astrocytes, ischemic myocytes, endothelial cells) has both pro …

[HTML][HTML] Interleukin-6 and Its Soluble Receptor Complex in Intensive Care Unit COVID-19 Patients: An Analysis of Second Wave Patients

G Di Spigna, D Spalletti Cernia, B Covelli, M Vargas… - Pathogens, 2023 - mdpi.com
In December 2019, a SARS-CoV-2 virus, coined Coronavirus Disease 2019 (COVID-19),
discovered in Wuhan, China, affected the global population, causing more than a million …

The bio-mission of interleukin-6 in the pathogenesis of COVID-19: A brief look at potential therapeutic tactics

M Abbasifard, H Khorramdelazad - Life sciences, 2020 - Elsevier
Abstract Interleukin-6 (IL-6), known as an inflammatory cytokine, can be involved in many
innate and adaptive immune responses. The role of IL-6 in the pathogenesis of the novel …

Relationship between IL-6 and COVID-19: to be considered during treatment

HS Vatansever, E Becer - Future Virology, 2020 - Future Medicine
The detection and control of pro-inflammatory response is crucial in the early stages of viral
infection. Coronavirus disease 2019 (COVID-19) is an emerging viral disease of global …

CHARACTERIZING THE TYPE OF INTERLEUKIN-6 SIGNALING IN SEVERE COVID-19

A Mahmud-Al-Rafat - 2023 - dalspace.library.dal.ca
Since the beginning of coronavirus disease-19 (COVID-19) pandemic many efforts were
made to explore the role of interleukin-6 (IL-6) in COVID-19. I used severe non-COVID-19 to …

[HTML][HTML] The role of IL-6 in coronavirus, especially in COVID-19

X Wang, G Tang, Y Liu, L Zhang, B Chen… - Frontiers in …, 2022 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infects both people and
animals and may cause significant respiratory problems, including lung illness: Corona …