Recent epidemiological, clinical, and experimental data suggest that cholesterol may play a
role in Alzheimer's disease (AD). We have recently shown that cholesterolemia has a …

Recent results implicating cholesterol metabolism in the pathophysiology of Alzheimer's
disease (AD) bring cholesterol to the forefront of AD research. Research from genetics …

Alzheimer's disease (AD), the most common form of dementia, is characterized by the
progressive loss of neurons and synapses, and by extracellular deposits of amyloid‐β (Aβ) …

The implication that cholesterol plays an essential role in the pathogenesis of Alzheimer's
disease (AD) is based on the 1993 finding that the presence of apolipoprotein E (apoE) …

A leading hypothesis on the pathophysiology of Alzheimer's disease (AD) is the mis-
metabolism of amyloid precursor protein. This mis-metabolism causes the 42-amino acid …

A large amount of evidence suggests a pathogenic link between cholesterol homeostasis
dysregulation and Alzheimer's disease (AD). In cell culture systems, the production of …

Cholesterol has been implicated in the pathogenesis of Alzheimer's disease, both through
intracellular effects, and through an extracellular effect due to its physical interaction with …

Epidemiological, animal, and cellular studies suggest that abnormalities in cholesterol
metabolism are important in the pathogenesis of Alzheimer's disease (AD), potentially by …

Fundamental questions on the pathogenesis of Alzheimer's disease (AD) are how nontoxic,
soluble amyloid β‐protein (Aβ) is converted to its toxic, aggregated form and how functional …

Several recent reports provided important knowledge on how “inhibiting cholesterol
production in the brain might inhibit amyloid b (Ab) ABBR production, and reduce the …