[HTML][HTML] Ethnic and trans-ethnic genome-wide association studies identify new loci influencing Japanese Alzheimer's disease risk

D Shigemizu, R Mitsumori, S Akiyama… - Translational …, 2021 - nature.com
Alzheimer's disease (AD) has no cure, but early detection and risk prediction could allow
earlier intervention. Genetic risk factors may differ between ethnic populations. To discover …

Transethnic genome‐wide scan identifies novel Alzheimer's disease loci

GR Jun, J Chung, J Mez, R Barber… - Alzheimer's & …, 2017 - Wiley Online Library
Abstract Introduction Genetic loci for Alzheimer's disease (AD) have been identified in whites
of European ancestry, but the genetic architecture of AD among other populations is less …

Association of GWAS-linked loci with late-onset Alzheimer's disease in a northern Han Chinese population

L Tan, JT Yu, W Zhang, ZC Wu, Q Zhang, QY Liu… - Alzheimer's & …, 2013 - Elsevier
Objective Five genomewide association studies (GWAS) in white populations have recently
identified and confirmed 9 novel Alzheimer's disease (AD) susceptibility loci (CLU, CR1 …

New light on an old CLU

L Bertram, RE Tanzi - Nature Reviews Neurology, 2010 - nature.com
Genome-wide association studies (GWAS) have uncovered over two dozen candidate
Alzheimer disease susceptibility genes; however, the results of these studies showed limited …

[HTML][HTML] Meta-analysis of Alzheimer's disease on 9,751 samples from Norway and IGAP study identifies four risk loci

A Witoelar, A Rongve, IS Almdahl, ID Ulstein… - Scientific reports, 2018 - nature.com
A large fraction of genetic risk factors for Alzheimer's Disease (AD) is still not identified,
limiting the understanding of AD pathology and study of therapeutic targets. We conducted a …

Genome-wide association studies in Alzheimer's disease

L Bertram, RE Tanzi - Human molecular genetics, 2009 - academic.oup.com
Genome-wide association studies (GWAS) have gained considerable momentum over the
last couple of years for the identification of novel complex disease genes. In the field of …

African ancestry GWAS of dementia in a large military cohort identifies significant risk loci

R Sherva, R Zhang, N Sahelijo, G Jun, T Anglin… - Molecular …, 2023 - nature.com
While genome wide association studies (GWASs) of Alzheimer's Disease (AD) in European
(EUR) ancestry cohorts have identified approximately 83 potentially independent AD risk …

Association of GWAS top hits with late-onset Alzheimer disease in Korean population

SJ Chung, JH Lee, SY Kim, S You, MJ Kim… - Alzheimer Disease & …, 2013 - journals.lww.com
Recent genome-wide association studies (GWAS) have discovered several Alzheimer
disease (AD) susceptibility loci. However, the identified susceptibility loci are substantially …

[HTML][HTML] Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease

J Lake, C Warly Solsberg, JJ Kim, J Acosta-Uribe… - Molecular …, 2023 - nature.com
Genome-wide association studies (GWAS) of Alzheimer's disease are predominantly carried
out in European ancestry individuals despite the known variation in genetic architecture and …

Genome-wide association studies for Alzheimer's disease: bigger is not always better

V Escott-Price, J Hardy - Brain Communications, 2022 - academic.oup.com
As the size of genome-wide association studies increase, the number of associated trait loci
identified inevitably increase. One welcomes this if it allows the better delineation of the …