Peripheral nerve injury commonly leads to neuropathic pain states fostered, in part, by
neuroimmunologic events. We used two models of neuropathic pain (L5 spinal nerve …

Mounting evidence supports the hypothesis that spinal microglia modulate the development
and maintenance of some chronic pain states. Here we examined the role of spinal …

Nerve injury leads to central neuroimmunologic responses that may be integral to the
development and maintenance of chronic neuropathic pain in humans. Recent data have …

A number of rat peripheral neuropathy models have been developed to simulate human
neuropathic pain conditions. The current study sought to determine the relative importance …

The pharmacological attenuation of glial activation represents a novel approach for
controlling neuropathic pain, but the role of microglial and astroglial cells is not well …

Partial sciatic nerve injury is a common model of neuropathic pain in rodents, and produces
both mechanical and thermal pain hypersensitivity. Several types of immune cells have …

Activated spinal glial cells have been strongly implicated in the development and
maintenance of persistent pain states following a variety of stimuli including traumatic nerve …

Peripheral nerve injuries that provoke neuropathic pain are associated with microglial
activation in the spinal cord. We have investigated the characteristics of spinal microglial …

Microglia are the resident macrophages in the central nervous system (CNS). Any insult to
the CNS homeostasis will induce a rapid change in microglia morphology, gene expression …

Traumatic spinal cord injury (SCI) results not only in motor impairment but also in chronic
central pain, which can be refractory to conventional treatment approaches. It has been …