Left ventricular remodeling after acute myocardial infarction: clinical course and beneficial effects of angiotensin-converting enzyme inhibition

GA Lamas, MA Pfeffer - American heart journal, 1991 - Elsevier
LV enlargement is an important determinant of survival after AMI. Pathyphosiologic
mechanisms leading to LV dilatation after an AMI include early thinning and stretching of the …

Left ventricular remodeling after acute myocardial infarction

MA Pfeffer, MD, Ph. D - Annual review of medicine, 1995 - annualreviews.org
▪ Abstract The loss of myocytes as a consequence of myocardial infarction results in a
prompt reduction in regional wall motion and often leads to more protracted and progressive …

Role of angiotensin converting enzyme inhibitors in preventing left ventricular remodelling following myocardial infarction

MA Konstam - European heart journal, 1995 - academic.oup.com
Progressive changes typically occur in left ventricular (LV) architecture following moderate-
to large-sized myocardial infarction (MI). These changes include early expansion and …

Effect of angiotensin-converting enzyme inhibitors on ventricular remodeling and survival following myocardial infarction

C Beckwith, MA Munger - Annals of Pharmacotherapy, 1993 - journals.sagepub.com
OBJECTIVE: To discuss the effects of angiotensin-converting enzyme (ACE) inhibitors on
ventricular remodeling and survival after acute myocardial infarction (AMI). An overview is …

Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications.

MA Pfeffer, E Braunwald - Circulation, 1990 - Am Heart Assoc
An acute myocardial infarction, particularly one that is large and transmural, can produce
alterations in the topography of both the infarcted and noninfarcted regions of the ventricle …

Ventricular enlargement following infarction is a modifiable process

MA Pfeffer, E Braunwald - The American journal of cardiology, 1991 - Elsevier
The dilation and distortion of the left ventricle that may occur as a consequence of
myocardial infarction are associated with a heightened risk for adverse cardiovascular …

Angiotensin converting enzyme inhibitors and cardiovascular remodelling.

DE Vaughan, MA Pfeffer - Cardiovascular research, 1994 - europepmc.org
Regional alterations in left ventricular function are generally present in patients who sustain
an acute myocardial infarction. Segmental wall motion abnormalities in left ventricular …

Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction: results of the Survival and Ventricular Enlargement …

MA Pfeffer, E Braunwald, LA Moyé… - New England journal …, 1992 - Mass Medical Soc
Background. Left ventricular dilatation and dysfunction after myocardial infarction are major
predictors of death. In experimental and clinical studies, long-term therapy with the …

Progressive ventricular dilation in experimental myocardial infarction and its attenuation by angiotensin-converting enzyme inhibition

JM Pfeffer - The American journal of cardiology, 1991 - Elsevier
The extent to which the impaired left ventricle dilates may have important prognostic
implications for survival. To determine the influence of infarct size and duration on …

Ventricular remodeling following myocardial infarction

N Sharpe - The American journal of cardiology, 1992 - Elsevier
Ventricular remodeling denotes structural changes that occur in ventricular chamber size,
wall thickness, and composition following myocardial damage. Following acute coronary …