Inflammatory lung injury is characterized by lung endothelial cell (LEC) death, alveolar
epithelial cell (AEC) death, LEC–LEC junction weakening, and leukocyte infiltration, which …

Hypoxia-inducible factors (HIFs) are transcription factors critical for the adaptive response to
hypoxia. There is also an essential link between hypoxia and inflammation, and HIFs have …

Acute lung injury (ALI) is an inflammatory lung disease that manifests itself in patients as
acute respiratory distress syndrome and thereby contributes significantly to the morbidity …

During the acute respiratory distress syndrome, epithelial cells, primarily alveolar type (AT) I
cells, die and slough off, resulting in enhanced permeability. ATII cells proliferate and spread …

Endothelial barrier dysfunction is a central factor in the pathogenesis of persistent lung
inflammation and protein-rich edema formation, the hallmarks of acute respiratory distress …

Acute lung injury (ALI) is an acute hypoxic respiratory insufficiency caused by various intra‐
and extrapulmonary injury factors. Presently, excessive inflammation in the lung and the …

Since the discovery of hypoxia-inducible factor (HIF), numerous studies on the hypoxia
signaling pathway have been performed. The role of HIF stabilization during hypoxia has …

Acute lung injury (ALI) is characterized by non-cardiogenic diffuse alveolar damage and
often leads to a lethal consequence, particularly when hypoxia coexists. The treatment of ALI …

Cellular responses to oxygen fluctuations are largely mediated by hypoxia-inducible factors
(HIFs). Upon inhalation, the first organ inspired oxygen comes into contact with is the lungs …

Background While acute lung injury (ALI) contributes significantly to critical illness, it
resolves spontaneously in many instances. The majority of patients experiencing ALI require …