Drug resistance is one of the major obstacles for successful chemotherapy of malignant
tumors including cervical cancer. To overcome this problem, a lot of efforts have been made …

The therapeutic index for chemotherapeutic drugs is determined in part by systemic toxicity,
so strategies for dose intensification to improve efficacy must also address tolerability. In …

Maytansine and its related analogues are a class of highly potent anti-proliferation agents
that have failed to be exploited as clinical drugs for human therapy due to unacceptable …

Cabazitaxel (CTX) exhibits stronger antineoplastic activity than paclitaxel and docetaxel
owing to its capacity to circumvent taxane resistance. However, the therapeutic index of CTX …

Multidrug resistance (MDR) is one of the main causes of the failure in cancer chemotherapy.
To address this challenge, this work develops a tumor-triggered nanomedicine (HA-MSDOX …

Nano‐prodrugs usually involve a multistep synthesis which largely compromises their
benefits. Here, a smart nano‐prodrug platform with reactive drug loading, superb stability …

Carrier-free nanodrugs, generated via the straightforward small-molecule self-assembly of
anticancer drugs, provide a promising route for cancer chemotherapy. However, their low …

Carrier-free pure nanodrugs (PNDs) that are composed entirely of pharmaceutically active
molecules are regarded as promising candidates to be the next generation of drug …

Multidrug resistance (MDR) is one of the most important reasons for the failure of clinical
chemotherapy treatment of cancer patients. Although several strategies have been …

Malignancies treated by insoluble targeted agents show low dose exposure and therapeutic
responses, therefore easily develop drug resistance. Nanoparticle-modified drugs might …