The NLRP3 inflammasome is implicated in the processing of the pro-inflammatory cytokine
interleukin 1β. Inflammatory disorders associated with the activation of the NLRP3 …

Abstract The NACHT, LRR, and PYD-domains-containing protein 3 (NLRP3) inflammasome
is an intracellular multi-protein signaling platform that is activated by cytosolic pattern …

Objective The NLRP 3 inflammasome is closely linked to the pathophysiology of a wide
range of inflammatory diseases. This study was undertaken to identify small molecules that …

Gout arthritis (GA) is a common and curable type of inflammatory arthritis that has been
attributed to a combination of genetic, environmental and metabolic factors. Chronic …

Gout is an inflammatory arthritis characterized by abrupt self-limiting attacks of inflammation
caused by precipitation of monosodium urate crystals (MSU) in the joint. Recent studies …

IL-1β is a cytokine with major roles in inflammation and innate immune responses. IL-1β is
produced as an inactive proform that must be cleaved within the cell to generate biologically …

Objective. To investigate the effects of soluble uric acid (UA) on expression and activation of
the NOD-like receptor (NLR) pyrin domain containing protein 3 (NLRP3) inflammasome in …

An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic
inflammation. Recent studies suggest that the triggering of IL-1β release from leucocytes lies …

Gouty arthritis is caused by the deposition of uric acid crystals, which induce the activation of
NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome. The NLRP3 …

The inflammasome is a molecular platform that is created in the cytosolic compartment to
mediate the host immunological response to cellular injury and infection. Caspase-1 may be …