Despite recent advances both in the chemistry and molecular pharmacology of antidiabetic
drugs, diabetes still remains a life‐threatening disease, which tends to spread all over the …

The results of recent clinical trials emphasise the importance of an improved glycaemic
control in diabetic patients in order to prevent or at least to delay long-term complications …

Although the administration of insulin can prolong the life of diabetics, its use to date has not
prevented the debilitating, late-onset complications associated with this disease. Diabetic …

The development of long-term diabetic complications in diabetes patients is considered to
be closely related to hyperglycaemia. Aldose reductase was first found to be implicated in …

The etiology of late-onset diabetic complications is not clear yet but is probably multifactorial,
and related to the quality of glycemic control [l-3] and to genetic factors. Several general …

Patients suffering from the severe complications associated with both insulin-(IDDM) and
noninsulin-dependent diabetes mellitus (NIDDM): nephropathy, retinopathy, neuropathy …

Diabetes mellitus has become a major health threat as a global rise in it has been seen. The
chronic disease has afflicted over 171 million people worldwide in 2000 and the incidence is …

Diabetes is often accompanied by several long-term complications such as neuropathy,
nephropathy, retinopathy, cataract and angiopathy; their occurrence has been linked to the …

Diabetes mellitus, a disorder of metabolism, results in the elevation of glucose level in the
blood. In this hyperglycaemic condition, aldose reductase overexpresses and leads to …

Publisher Summary Several excellent reviews of the recent advances in the understanding
of the biochemical events contributing to the pathophysiology of diabetic complications have …