Intratumoral heterogeneity is among the greatest challenges in precision cancer therapy.
However, developments in high-throughput single-cell RNA sequencing (scRNA-seq) may …

Effective cancer treatment has been precluded by the presence of various forms of
intratumoral complexity that drive treatment resistance and metastasis. Recent single-cell …

Intratumor heterogeneity is a common characteristic across diverse cancer types and
presents challenges to current standards of treatment. Advancements in high-throughput …

Cellular heterogeneity within and across tumors has been a major obstacle in
understanding and treating cancer, and the complex heterogeneity is masked if bulk tumor …

Unlike population-level approaches, single-cell RNA sequencing enables transcriptomic
analysis of an individual cell. Through the combination of high-throughput sequencing and …

Extensive genomic and transcriptomic heterogeneity in human cancer often negatively
impacts treatment efficacy and survival, thus posing a significant ongoing challenge for …

Cancers are a group of heterogeneous diseases characterized by the acquisition of
functional capabilities during the transition from a normal to a neoplastic state. Powerful …

Cancer is a heterogeneous disease with unique genomic and phenotypic features that differ
between individual patients and even among individual tumor regions. In recent years, large …

Tumor heterogeneity is a major hindrance in cancer classification, diagnosis and treatment.
Recent technological advances have begun to reveal the true extent of its heterogeneity …

Single-cell sequencing (SCS) has impacted many areas of cancer research and improved
our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and …