Autoactivation and calpain-1-mediated shedding of hepsin in human hepatoma cells

L Wang, C Zhang, S Sun, Y Chen, Y Hu… - Biochemical …, 2019 - portlandpress.com
Hepsin is a transmembrane serine protease implicated in many biological processes,
including hepatocyte growth, urinary protein secretion, auditory nerve development, and …

Antibodies neutralizing hepsin protease activity do not impact cell growth but inhibit invasion of prostate and ovarian tumor cells in culture

JA Xuan, D Schneider, P Toy, R Lin, A Newton, Y Zhu… - Cancer research, 2006 - AACR
Hepsin is a type II transmembrane serine protease that is expressed in normal liver, and at
lower levels in kidney, pancreas, and testis. Several studies have shown that hepsin mRNA …

Hepsin: a multifunctional transmembrane serine protease in pathobiology

S Li, L Wang, S Sun, Q Wu - The FEBS Journal, 2021 - Wiley Online Library
Cell membrane‐bound serine proteases are important in the maintenance of physiological
homeostasis. Hepsin is a type II transmembrane serine protease highly expressed in the …

[HTML][HTML] Hepsin promotes prostate cancer progression and metastasis

O Klezovitch, J Chevillet, J Mirosevich, RL Roberts… - Cancer cell, 2004 - cell.com
The majority of cancer-related deaths are associated with metastasis; however, little is
known about the mechanisms of this process. Hepsin is a cell surface serine protease that is …

Decreased expressions of hepsin in human hepatocellular carcinomas

CH Chen, KY Su, MH Tao, SW Lin, YH Su… - Liver …, 2006 - Wiley Online Library
Background/Aims: Hepsin is a type II transmembrane protein predominantly expressed in
the liver and has been implicated in participation in blood coagulation pathway and …

Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion

TA Tervonen, D Belitškin, SM Pant, JI Englund… - Oncogene, 2016 - nature.com
Hepsin belongs to a family of cell-surface serine proteases, which have sparked interest as
therapeutic targets because of the accessibility of extracellular protease domain for …

Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers

S Herter, DE Piper, W Aaron, T Gabriele… - Biochemical …, 2005 - portlandpress.com
Hepsin is a membrane-anchored, trypsin-like serine protease with prominent expression in
the human liver and tumours of the prostate and ovaries. To better understand the biological …

Identification and characterization of small-molecule inhibitors of hepsin

JR Chevillet, GJ Park, A Bedalov, JA Simon… - Molecular cancer …, 2008 - AACR
Hepsin is a type II transmembrane serine protease overexpressed in the majority of human
prostate cancers. We recently demonstrated that hepsin promotes prostate cancer …

Hepsin colocalizes with desmosomes and induces progression of ovarian cancer in a mouse model

J Miao, D Mu, B Ergel, R Singavarapu… - … journal of cancer, 2008 - Wiley Online Library
Hepsin is a serine protease that is widely expressed in different tissues and cell types, most
prominently in the normal liver and kidney. Overexpression of hepsin has been associated …

[PDF][PDF] Serine protease hepsin regulates hepatocyte size and hemodynamic retention of tumor cells by hepatocyte growth factor signaling in mice

YC Hsu, HP Huang, IS Yu, KY Su, SR Lin, WC Lin… - …, 2012 - Wiley Online Library
The liver architecture plays an important role in maintaining hemodynamic balance, but the
mechanisms that underlie this role are not fully understood. Hepsin, a type II transmembrane …