Point: Flow-mediated dilation does reflect nitric oxide-mediated endothelial function

D Green - Journal of Applied Physiology, 2005 - journals.physiology.org
Before you embark on this debate with my redoubtable Canadian friends, you may find it
advisable to take something to minimize your cardiovascular risk. I recommend the sensible …

[HTML][HTML] Counterpoint: Flow-mediated dilation does not reflect nitric oxide-mediated endothelial function

ME Tschakovsky, KE Pyke - Journal of applied physiology, 2005 - journals.physiology.org
The phenomenon of flow-mediated dilation (FMD) relevant to this debate describes the
vasodilation in a conduit vessel in response to elevations in flow-associated shear stress …

There's more to flow-mediated dilation than nitric oxide

L Stoner, ML Erickson, JM Young, S Fryer… - … of atherosclerosis and …, 2012 - jstage.jst.go.jp
The pathological complications of atherosclerosis, namely myocardial infarction and strokes,
remain the leading cause of mortality in the Western world1). Endothelial dysfunction …

Assessment of flow-mediated dilation in humans: a methodological and physiological guideline

DHJ Thijssen, MA Black, KE Pyke… - American Journal …, 2011 - journals.physiology.org
Endothelial dysfunction is now considered an important early event in the development of
atherosclerosis, which precedes gross morphological signs and clinical symptoms. The …

Nitric oxide is not obligatory for radial artery flow-mediated dilation following release of 5 or 10 min distal occlusion

K Pyke, DJ Green, C Weisbrod… - American Journal …, 2010 - journals.physiology.org
This study investigated the nitric oxide (NO) dependence of radial artery (RA) flow-mediated
dilation (FMD) in response to three different reactive hyperemia (RH) shear stimulus profiles …

Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter?

DJ Green, H Jones, D Thijssen, NT Cable… - Hypertension, 2011 - Am Heart Assoc
Endothelial dysfunction is an early atherosclerotic event that precedes clinical symptoms
and may also render established plaque vulnerable to rupture. Noninvasive assessment of …

Evaluation of endothelial function by flow mediated dilation: methodological issues and clinical importance

L Ghiadoni, M Salvetti, ML Muiesan… - High blood pressure & …, 2015 - Springer
Endothelium plays a primary role in the control of vascular function and structure by
protective properties of nitric oxide, which have stimulated the development of methods to …

Is flow-mediated dilation nitric oxide mediated? A meta-analysis

DJ Green, EA Dawson, HMM Groenewoud, H Jones… - …, 2014 - Am Heart Assoc
Flow-mediated dilation (FMD) is a noninvasive index of endothelial function and vascular
health in humans. Studies examining the role of nitric oxide (NO) are not conclusive. In this …

Examining the acute effects of retrograde versus low mean shear rate on flow-mediated dilation

JC Tremblay, AS Grewal… - Journal of Applied …, 2019 - journals.physiology.org
Arterial endothelial function is acutely and chronically regulated by blood flow-associated
shear stress. An acute intervention employing modest forearm cuff occlusion to …

Heterogenous vasodilator pathways underlie flow-mediated dilation in men and women

BA Parker, ME Tschakovsky… - American Journal …, 2011 - journals.physiology.org
This study investigated the sex differences in the contribution of nitric oxide (NO) and
prostaglandins (PGs) to flow-mediated dilation (FMD). Radial artery (RA) FMD, assessed as …