Background The axolotl is a key model to study appendicular regeneration. The limb
complexity resembles that of humans in structure and tissue components; however, axolotl …

Abstract The Mexican Axolotl is one of the few tetrapod species that is capable of
regenerating complete skeletal elements in injured adult limbs. Whether the skeleton (bone …

Axolotl salamanders (Ambystoma mexicanum) remain aquatic in their natural state, during
which biomechanical forces on their diarthrodial limb joints are likely reduced relative to …

The existing table of stages of the normal development of the axolotl (Ambystoma
mexicanum) ends just after hatching. At this time, the forelimbs are small buds. In this study …

Matching appendage size to body size is fundamental to animal function. Generating an
appropriately-sized appendage is a robust process executed during development which is …

Salamanders show unparalleled capacities of tissue regeneration amongst tetrapods (four‐
legged vertebrates), being able to repair and renew lost or damage body parts, such as tails …

The experimental study of amphibian limb regeneration spans most of the 20th century and
the first decade of the 21st century. We first review the major questions investigated over this …

Among vertebrates, urodele amphibians (eg, axolotls) have the unique ability to perfectly
regenerate complex body parts after amputation. The limb has been the most widely studied …

Primary body axis development is a highly conserved process that proceeds through
somitogenesis and further subdivision into dermatome, myotome, and sclerotome. Defects in …

Background The endogenous ability to dedifferentiate, re-pattern, and re-differentiate adult
cells to repair or replace damaged or missing structures is exclusive to only a few tetrapod …