In the present study, the expression of P53 and MDM2 proteins were examined in
specimens from a group of 20 patients (9 with primary hepatocellular carcinoma HCC and …

The relationship between mdm2 gene expression and p53 gene mutation in hepatocellular
carcinoma (HCC) and their correlation with the invasiveness of the disease were …

Aberration of the p53 gene is thought to be the most frequent genetic alteration in human
cancers. Tp53 protein may be inactivated by the binding of the MDM2 protein. MDM2, the …

Background/Aims: The transcription of mdm2 gene is activated by p53 and this limits the
growth‐suppressing activity of p53 by direct binding. It has been reported that MDM2 protein …

The aim of our study was to investigate the expression of p53 and mdm2 mRNA and protein
in colorectal adenocarcinoma. For the detection of mRNA, 60 fresh frozen human tumour …

Aims-To investigate the correlation between the expression of the p53 and mdm-2
oncoproteins and to assess their prognostic value in colorectal cancer. Methods-Using a …

This study investigates the mdm2 gene status and expression in 66 surgically resected
human breast carcinomas, with correlations with clinico‐pathological and biological data …

Tumor suppressor protein p53 is a positive regulator of MDM2 gene expression and the
mdm2 protein can bind to p53, preventing the transactivation of p53 responsive genes, thus …

AIMS: To evaluate the respective roles of mdm2 (murine double minute 2) and p53 in the
development of colorectal carcinoma. METHODS: Formalin fixed, paraffin wax embedded …

Fifty-three non-small cell lung carcinomas (NSCLC), previously investigated for p53
abnormalities, were studied to evaluate the status of the mdm2 gene by Southern and …