The efficacy of drug therapy results from the complex interplay of multiple processes that
govern drug disposition and response. Most studies to date have focused on the contribution …

Drug transporters are critically important for the absorption, distribution, metabolism, and
excretion (ADME) of many drugs and endogenous compounds. Therefore, disruption of …

Membrane transport proteins are involved in the absorption, disposition, efficacy, and/or
toxicity of many drugs. Numerous mechanisms (eg, nuclear receptors, epigenetic gene …

Since 1994, researchers have isolated various genes encoding transporter proteins
involved in drug uptake into and eŒux from tissues that play key roles in the absorption …

Recently, increased interest in drug transporters and research in this area has revealed that
drug transporters play an important role in modulating drug absorption, distribution, and …

A comprehensive guide to drug transporters that influence the absorption, distribution, and
elimination of drugs in the body The development of powerful expression cloning and …

Drug transporters play an essential role in disposition and effects of multiple drugs. Plasma
concentrations of the victim drug can be modified by drug–drug interactions occurring in …

Transporters comprise the largest family of membrane proteins in human organism,
including members of solute carrier transporter and ATP-binding cassette transporter …

Transport proteins play an important role in the adsorption, distribution and elimination of a
wide variety of drugs. Therefore, it is not surprising that transporter-based drug interactions …

This white paper addresses current approaches and knowledge gaps concerning methods
to assess the role of transport proteins in drug/metabolite disposition in humans. The …