Precision medicine characterizes a new era of cancer care and provides each patient with
the right drug at the right dose and time. However, the practice of precision dosing is …

Background: Recent studies suggest that 5-fluorouracil (5-FU) dosing by use of
pharmacokinetic (PK) parameters is superior to the traditional body surface area (BSA) …

Despite advances in targeted cancer therapy, the fluoropyrimidines 5‐fluorouracil (5FU) and
capecitabine continue to play an important role in oncology. Historically, dosing of these …

e14561 Background: 5-FU has been the backbone of systemic combination chemotherapy
for treatment of CRC in the adjuvant and metastatic disease settings. The dosing of 5-FU has …

Recently, therapeutic drug monitoring of 5-fluorouracil (5-FU), the key chemotherapeutic
drug for colorectal cancer, has been applied in daily clinical practice and has contributed …

Chemotherapy dosing of the fluoropyrimidine 5-fluorouracil (5-FU) is currently based on
body surface area. However, body surface area–based dosing has been associated with …

Fluorouracil (5-FU) response prediction and therapeutic drug monitoring (TDM) are required
to minimize toxicity while preserving efficacy. Conventional 5-FU dose normalization uses …

Background Pharmacokinetic guided dosing of 5-fluorouracil chemotherapies to bring
plasma 5-fluorouracil into a desired therapeutic range may lead to fewer side effects and …

3574 Background: Multiple studies have demonstrated how PK-guided dosing to optimize
infusional 5FU exposure improves both response rates and toxicities. With 5FU PK testing …

Abstract Purpose For over 50 years, 5-FU has played a critical role in the systemic
chemotherapy of cancer patients. 5-FU serves as the main backbone of combination …