Roles for long non-coding RNAs in physiology and disease

MT Melissari, P Grote - Pflügers Archiv-European Journal of Physiology, 2016 - Springer
While the vast majority of the genome is transcribed into RNA, only a small fraction of these
transcripts have protein-coding potential. A large fraction of the transcribed RNA belongs to …

Molecular functions and biological roles of long non‐coding RNAs in human physiology and disease

F Kopp - The journal of gene medicine, 2019 - Wiley Online Library
The human genome has been demonstrated to be pervasively transcribed, with a large
fraction of the transcriptome representing non‐protein‐coding RNA species. A relatively …

[HTML][HTML] Long non-coding RNAs: novel regulators of cellular physiology and function

JA Oo, RP Brandes, MS Leisegang - Pflügers Archiv-European Journal of …, 2022 - Springer
Long non-coding RNAs were once considered as “junk” RNA produced by aberrant DNA
transcription. They are now understood to play central roles in diverse cellular processes …

Long noncoding RNA: its physiological and pathological roles

B Yan, Z Wang - DNA and Cell Biology, 2012 - liebertpub.com
Long noncoding RNAs (lncRNAs) are transcribed RNA molecules> 200 nucleotides in
length. They comprise a diverse class of transcripts that structurally resemble mRNAs, but do …

[HTML][HTML] Regulatory long non-coding RNA and its functions

Y Huang, N Liu, JP Wang, YQ Wang, XL Yu… - Journal of physiology …, 2012 - Springer
The discovery of large numbers of long non-coding RNAs (lncRNAs) has been driven by
genome-wide transcriptional analyses. Compared to small ncRNAs, lncRNAs have been …

[HTML][HTML] Besides pathology: long non-coding RNA in cell and tissue homeostasis

A Salviano-Silva, SC Lobo-Alves, RC Almeida… - Non-coding RNA, 2018 - mdpi.com
A significant proportion of mammalian genomes corresponds to genes that transcribe long
non-coding RNAs (lncRNAs). Throughout the last decade, the number of studies concerning …

[HTML][HTML] Mechanisms of long noncoding RNA function in development and disease

SU Schmitz, P Grote, BG Herrmann - Cellular and molecular life sciences, 2016 - Springer
Since decades it has been known that non-protein-coding RNAs have important cellular
functions. Deep sequencing recently facilitated the discovery of thousands of novel …

Long noncoding RNAs: insights from biological features and functions to diseases

X Li, Z Wu, X Fu, W Han - Medicinal research reviews, 2013 - Wiley Online Library
Over the past decade, genome‐wide transcriptomic studies have shown that the mammalian
genome is pervasively transcribed and produces many thousands of transcriptomes without …

Long noncoding RNA: genomics and relevance to physiology

Y Kong, Z Lu, P Liu, Y Liu, F Wang… - Comprehensive …, 2011 - Wiley Online Library
The mammalian cell expresses thousands of long noncoding RNAs (lncRNAs) that are
longer than 200 nucleotides but do not encode any protein. lncRNAs can change the …

Long non-coding RNA: Functional agent for disease traits

S Jain, N Thakkar, J Chhatai, M Pal Bhadra… - RNA biology, 2017 - Taylor & Francis
In recent years, long non-coding RNAs (lncRNAs) have attracted the attention of researchers
with their involvement in all facets of life. LncRNAs are transcripts of more than 200 …