Creating a functional vascularized bone tissue remains one of the main goals of bone tissue
engineering. Recently, a growing interest in the crosstalk between endothelial cells (EC) …

Bone development and remodeling depend on complex interactions between bone-forming
osteoblasts and other cells present within the bone microenvironment, particularly …

Vascularization is important for bone development, fracture healing and engineering of
artificial bone tissue. In the context of bone tissue engineering, it was shown that …

Association of the bone‐forming osteoblasts (OBs) and vascular endothelial cells (ECs) into
a biomaterial composite provides a live bone graft substitute that can repair the bone defect …

The most promising strategies in bone engineering have concentrated on providing
sufficient vascularization to support the newly forming tissue. In this context, recent research …

Coculturing of bone‐forming and blood vessel‐forming cells is a strategy aimed at
increasing vascularity of implanted bone constructs in tissue‐engineering applications. We …

Angiogenesis is a fundamental process in bone formation, remodeling, and regeneration.
Moreover, for the regeneration of bone in tissue engineering applications, it is essential to …

The repair of bone defects caused by trauma, infection or tumor resection is a major clinical
orthopedic challenge. The application of bone grafts in orthopedic procedures is associated …

Background Improved understanding of the interactions between bone cells and endothelial
cells involved in osteogenesis should aid the development of new strategies for bone tissue …

Bone tissue is a highly vascularized and dynamic system with a complex construction. In
order to develop a construct for implant purposes in bone tissue engineering, a proper …