Purpose To develop a limited sampling strategy (LSS) to predict area under the
concentration–time curve (AUC) ratios of omeprazole (AUC OPZ) to its metabolites 5 …

Objective The purpose of this study was to identify the common time point to achieve
hydroxylation index (HI: omeprazole plasma concentration/5-hydroxyomeprazole plasma …

To determine if dose dependency occurs with 2 weight‐based single doses of omeprazole
in a phenotyping study as well as to quantitate 3‐month intraindividual variability of …

Cytochrome P450 (CYP) 2C19 (CYP2C19) genotype is regarded as a useful tool to predict
area under the blood concentration-time curve (AUC) of proton pump inhibitors (PPIs). In our …

Purpose The purpose of this study is to evaluate the ethnicity-specific population models in
the SimCYP Simulator® for prediction of omeprazole clearance with attention to differences …

Physiologically based pharmacokinetic (PBPK) modeling has a number of applications,
including assessing drug–drug interactions (DDIs) in polymorphic populations, and should …

Omeprazole is an established probe drug to assess cytochrome P450 (CYP) 2C19 activity
(phenotyping). Because it has nonlinear pharmacokinetics (PK) after oral administration …

Aim: To align predicted and measured CYP2C19 phenotype in a South African cohort.
Materials & methods: Genotyping of CYP2C19* 2,* 3,* 9,* 15,* 17,* 27 and* 28 was …

Purpose To develop a whole physiologically based pharmacokinetic-pharmacodynamic
(PBPK-PD) model to describe the pharmacokinetics and anti-gastric acid secretion of …

Purpose Omeprazole has (R)-and (S)-enantiomers, which exhibit different pharmacokinetics
(PK) among patients with cytochrome P450 (CYP) 2C19 genotype groups. The aim of this …