Background Our objective was to study omeprazole as a single‐dose oral probe in the
determination of CYP2C19 phenotype in black subjects and to determine the correlation …

The aim of this study was to evaluate the contribution of metabolites to drug-drug
interactions (DDI) using the inhibition of CYP2C19 and CYP3A4 by omeprazole and its …

Omeprazole and sodium bicarbonate dry suspension are effective treatments for acid-
related disorders. This study compared the bioequivalence and safety of the two …

Objectives: Omeprazole is metabolized mainly by CYP2C19 which has two major mutations
(CYP2C19* 2 in exon5 and CYP2C19* 3 in exon4) associated with the poor metabolizer …

The objective of this study was to identify a single time-point for plasma lansoprazole
measurement that adequately reflects area under the plasma lansoprazole concentration …

Nonlinear kinetics of omeprazole and its metabolites were investigated after treatment with
repeated high doses. Extensive metabolizers relating to cytochrome P450 2C19 (CYP2C19) …

Purpose To investigate the suitability of microdosed oral omeprazole for predicting
CYP2C19 activity in vivo in combination with simultaneous assessment of CYP3A and …

Understanding the influence of ethnicity on drug exposure is key to patient safety and could
minimize repetitive clinical studies. This analysis aimed to evaluate the ability of …

Background and objective: CYP2C19 is clinically important in Korea because of the
relatively high incidence of poor metabolizers in the population. To fully understand the …

Aims Omeprazole is mainly metabolized by the polymorphic cytochrome P450 (CYP) 2C19.
The inhibitory effect of fluvoxamine, an inhibitor of CYP2C19 as well as CYP1A2, on the …