Protein tyrosine phosphorylation has been implicated in normal and pathological functions
such as cell proliferation, migration and differentiation. Recently, some studies have shown …

The formalin test produces 2 well-known acute phases of nociceptive behavior. Recently, we
have shown that this same formalin test produces a third phase of nociceptive behavior …

Hypersensitivity to mechanical stimulation is a well documented symptom of neuropathic
pain, for which there is currently no effective therapy. Src-family kinases (SFKs) are involved …

Background Lumbar disc herniation is a major cause of radicular pain, but the underlying
mechanisms remain largely unknown. Spinal activation of src-family kinases are involved in …

We examined the effect of p38 mitogen‐activated protein kinase (MAPK) inhibitors in models
of nociception and correlated this effect with localization and expression levels of p38 MAPK …

The pharmacological attenuation of glial activation represents a novel approach for
controlling neuropathic pain, but the role of microglial and astroglial cells is not well …

Background Microglia might play an important role in nociceptive processing and
hyperalgesia by neuroinflammatory process. Mineralocorticoid receptor (MR) expressed on …

Neuropathic pain is a highly debilitating chronic pain state that is a consequence of nerve
injury or of diseases such as diabetes, cancer, infection, autoimmune disease, or trauma …

Stress has been shown to enhance pain sensitivity resulting in stress-induced hyperalgesia.
However, the underlying mechanisms have yet to be elucidated. Using single-prolonged …

Accumulating evidence suggests that activation of spinal microglia contributes to the
development of inflammatory and neuropathic pain. However, the role of spinal microglia in …