Clock genes create a complicated molecular time-keeping system consisting of multiple
positive and negative feedback loops at transcriptional and translational levels. This …

Recent studies have demonstrated the influence of clock genes in cell cycle regulation, cell
proliferation, apoptosis and DNA damage recognition and repair. There is evidence …

Simple Summary Colorectal cancer (CRC) belongs to the top three most common
malignancies and is one of the deadliest cancers worldwide. Advancements in the …

The circadian timing system controls about 40% of the transcriptome and is important in the
regulation of a wide variety of biological processes including metabolic and proliferative …

Colorectal cancer (CRC) is a lethal malignancy with limited treatment strategies.
Accumulating evidence indicates that CRC tumorigenesis, progression and metastasis are …

Dysregulation of the circadian timing system (CTS) frequently appears during colorectal
cancer (CRC) progression. In order to better understand the role of the circadian clock in …

The clock gene machinery controls cellular metabolism, proliferation, and key functions,
such as DNA damage recognition and repair. Dysfunction of the circadian clock is involved …

The circadian rhythm is generated at the cellular level by a molecular clock system that
involves specific genes. Studies have revealed that circadian clock disruption is a control …

The circadian clock regulates daily variations in physiologic processes. CLOCK acts as a
regulator in the circadian apparatus controlling the expression of other clock genes …

Colorectal cancer is the most prevalent among digestive system cancers. Carcinogenesis
relies on disrupted control of cellular processes, such as metabolism, proliferation, DNA …