Colchicine and aspirin in community patients with COVID-19 (ACT): an open-label, factorial, randomised, controlled trial

JW Eikelboom, SS Jolly, EP Belley-Cote… - The Lancet …, 2022 - thelancet.com
Background The large number of patients worldwide infected with the SARS-CoV-2 virus
has overwhelmed health-care systems globally. The Anti-Coronavirus Therapies (ACT) …

Colchicine and the combination of rivaroxaban and aspirin in patients hospitalised with COVID-19 (ACT): an open-label, factorial, randomised, controlled trial

JW Eikelboom, SS Jolly, EP Belley-Cote… - The Lancet …, 2022 - thelancet.com
Background COVID-19 disease is accompanied by a dysregulated immune response and
hypercoagulability. The Anti-Coronavirus Therapies (ACT) inpatient trial aimed to evaluate …

Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial

JC Tardif, N Bouabdallaoui, PL L'allier… - The Lancet …, 2021 - thelancet.com
Background Evidence suggests a role for excessive inflammation in COVID-19
complications. Colchicine is an oral anti-inflammatory medication beneficial in gout …

[HTML][HTML] Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

RECOVERY Collaborative Group - The Lancet Respiratory Medicine, 2021 - Elsevier
Background Colchicine has been proposed as a treatment for COVID-19 based on its anti-
inflammatory actions. We aimed to evaluate the efficacy and safety of colchicine in patients …

Colchicine use might be associated with lower mortality in COVID‐19 patients: A meta‐analysis

MN Elshafei, A El‐Bardissy, A Khalil… - European journal of …, 2021 - Wiley Online Library
Background Colchicine was recently repurposed for the management of coronavirus
disease 2019 (COVID‐19). This rapid review and meta‐analysis aimed to assess …

Impact of colchicine on mortality and morbidity in COVID-19: a systematic review

D Sanghavi, P Bansal, IP Kaur, MS Mughal… - Annals of …, 2022 - Taylor & Francis
Introduction Colchicine, because of its anti-inflammatory and possible anti-viral properties,
has been proposed as potential therapeutic option for COVID-19. The role of colchicine to …

Effect of colchicine on the outcomes of patients with COVID-19: a systematic review and meta-analysis of randomised controlled trials

SH Lan, CK Hsu, CC Lai, SP Chang, LC Lu… - Annals of …, 2022 - Taylor & Francis
Aim This meta-analysis aimed to assess the usefulness of colchicine in patients with COVID-
19. Methods PubMed, Web of Science, Ovid MEDLINE, the Cochrane Library, Embase, and …

Colchicine use in patients with COVID-19: A systematic review and meta-analysis

L Chiu, CH Lo, M Shen, N Chiu, R Aggarwal, J Lee… - PLoS …, 2021 - journals.plos.org
Introduction Colchicine may inhibit inflammasome signaling and reduce proinflammatory
cytokines, a purported mechanism of COVID-19 pneumonia. The aim of this systematic …

Colchicine is safe though ineffective in the treatment of severe COVID-19: a randomized clinical trial (COLCHIVID)

A Absalón-Aguilar, M Rull-Gabayet… - Journal of General …, 2022 - Springer
Background Colchicine is an available, safe, and effective anti-inflammatory drug and has
been suggested as a COVID-19 treatment, but its usefulness in hospitalized severe COVID …

Colchicine in recently hospitalized patients with COVID-19: a randomized controlled trial (COL-COVID)

DA Pascual-Figal, AE Roura-Piloto… - … Journal of General …, 2021 - Taylor & Francis
Background Colchicine has been proposed as a potential therapy in coronavirus disease
2019 (COVID-19) due to their anti-inflammatory actions. Methods The COL-COVID study …