Kinesins are enzymes that use the energy of ATP to perform mechanical work. There are
approximately 14 families of kinesins within the kinesin superfamily. Family classification is …

Microtubule‐based motor proteins play key roles during mitosis to assemble the bipolar
spindle, define the cell division axis, and align and segregate the chromosomes. The …

Chromosome segregation during cell division requires a bipolar mitotic spindle. Therefore,
how the spindle is formed, maintained, and functions is of fundamental importance for all …

In all eukaryotic cells, molecular motor proteins play essential roles in spindle assembly and
function. The homotetrameric kinesin-5 motors in particular generate outward forces that …

Kinesin-5 is required for forming the bipolar spindle during mitosis. Its motor domain, which
contains nucleotide and microtubule binding sites and mechanical elements to generate …

Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions.
Their motor domain drives these activities, but the molecular adaptations that specify these …

Mitotic cell division is the most fundamental task of all living cells. Cells have intricate and
tightly regulated machinery to ensure that mitosis occurs with appropriate frequency and …

Kinesin is but one member of a large superfamily of microtubule-based motor proteins. This
diverse group of motors drives a numer of essential subcellular movements, including …

During mitosis, the mitotic spindle is assembled to align chromosomes at the spindle
equator in metaphase, and to separate the genetic material equally to daughter cells in …

▪ Abstract The kinesin superfamily comprises a large and structurally diverse group of
microtubule-based motor proteins that produce a variety of force-generating activities within …