Adaptive designs allow planned modifications based on data accumulating within a study.
The promise of greater flexibility and efficiency stimulates increasing interest in adaptive …

Adaptive clinical trials are an innovative trial design aimed at reducing resources,
decreasing time to completion and number of patients exposed to inferior interventions, and …

Adaptive designs for clinical trials permit alterations to a study in response to accumulating
data in order to make trials more flexible, ethical, and efficient. These benefits are achieved …

Adaptive designs can make clinical trials more flexible by utilising results accumulating in
the trial to modify the trial's course in accordance with pre-specified rules. Trials with an …

Background The clinical trials community has a never-ending search for dependable and
reliable ways to improve clinical research. This exploration has led to considerable interest …

Although adaptive design methods are flexible and useful in clinical research, little or no
regulatory guidelines are available. One of the first books on the topic, Adaptive Design …

Adaptive designs promise the flexibility to redesign clinical trials at interim stages. This
flexibility would provide greater efficiency in drug development. However, despite this …

Adaptive Designs for Clinical Trials | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

Background Adaptive designs are a wide class of methods focused on improving the power,
efficiency and participant benefit of clinical trials. They do this through allowing information …

Adaptive designs play an increasingly important role in clinical drug development. Such
designs use accumulating data of an ongoing trial to decide how to modify design aspects …