Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection
Certain sulfated glycans, including those from marine sources, can show potential effects
against SARS-CoV-2. Here, a new fucosylated chondroitin sulfate (FucCS) from the sea …
against SARS-CoV-2. Here, a new fucosylated chondroitin sulfate (FucCS) from the sea …
Structural requirements of Holothuria floridana fucosylated chondroitin sulfate oligosaccharides in anti-SARS-CoV-2 and anticoagulant activities
Fucosylated chondroitin sulfate (FucCS) is a unique glycosaminoglycan found primarily in
sea cucumbers. This marine sulfated glycan is composed of a chondroitin sulfate backbone …
sea cucumbers. This marine sulfated glycan is composed of a chondroitin sulfate backbone …
Fractionation of sulfated galactan from the red alga Botryocladia occidentalis separates its anticoagulant and anti-SARS-CoV-2 properties
Sulfation pattern and molecular weight (MW) play a key role in the biological actions of
sulfated glycans. Besides anticoagulant effects, certain sulfated glycans can also exhibit anti …
sulfated glycans. Besides anticoagulant effects, certain sulfated glycans can also exhibit anti …
The structure-activity relationship of the interactions of SARS-CoV-2 spike glycoproteins with glucuronomannan and sulfated galactofucan from Saccharina japonica
The SARS-CoV-2 spike glycoproteins (SGPs) and human angiotensin converting enzyme 2
(ACE2) are the two key targets for the prevention and treatment of COVID-19. Host cell …
(ACE2) are the two key targets for the prevention and treatment of COVID-19. Host cell …
On the selectivity of heparan sulfate recognition by SARS-CoV-2 spike glycoprotein
JE Chittum, NV Sankaranarayanan… - ACS Medicinal …, 2021 - ACS Publications
SARS-CoV-2 infects human cells through its surface spike glycoprotein (SgP), which relies
on host cell surface heparan sulfate (HS) proteoglycans that facilitate interaction with the …
on host cell surface heparan sulfate (HS) proteoglycans that facilitate interaction with the …
Anti-SARS-CoV-2 and anticoagulant properties of Pentacta pygmaea fucosylated chondroitin sulfate depend on high molecular weight structures
Fucosylated chondroitin sulfate (FucCS) is a unique marine glycosaminoglycan that exhibits
diverse biological functions, including antiviral and anticoagulant activity. In previous work …
diverse biological functions, including antiviral and anticoagulant activity. In previous work …
Heparan sulfate proteoglycans as attachment factor for SARS-CoV-2
Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) is causing an
unprecedented global pandemic demanding the urgent development of therapeutic …
unprecedented global pandemic demanding the urgent development of therapeutic …
Anti-SARS-CoV-2 Activity of Rhamnan Sulfate from Monostroma nitidum
The COVID-19 pandemic is a major human health concern. The pathogen responsible for
COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), invades its host …
COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), invades its host …
Holothurian fucosylated chondroitin sulfates and their potential benefits for human health: Structures and biological activities
Fucosylated chondroitin sulfates (FCS) are a sulfated polysaccharide exclusively existing in
the body wall of sea cucumber. FCS possesses a mammalian chondroitin sulfate like …
the body wall of sea cucumber. FCS possesses a mammalian chondroitin sulfate like …
Potential anti-SARS-CoV-2 activity of pentosan polysulfate and mucopolysaccharide polysulfate
With the increased prevalence of new SARS-CoV-2 variants of concern, such as Delta and
Omicron, the COVID-19 pandemic has become an ongoing human health disaster, killing …
Omicron, the COVID-19 pandemic has become an ongoing human health disaster, killing …