BACKGROUND: Some cases of recurrent miscarriage and later pregnancy complications
have a thrombotic basis. Factor V Leiden is a common thrombophilic mutation. METHODS …

Abstract BACKGROUND: Factor V Leiden mutation (Arg506Gln) increases the likelihood of
venous thrombosis; it may also have a positive effect through facilitation of embryo …

Some investigators suggest that placental thrombosis and infarction can cause recurrent
miscarriage. We have shown that the common missense mutation in the factor V gene, the …

The Leiden mutation is a recent discovery. It is the main cause of inherited thrombophilia
and has been found in 20–60% of deep vein thrombosis cases. More recently it has been …

Background: Recurrent pregnancy loss may result from hypercoagulability. Objective: To
determine whether women with factor V Leiden mutation, a common inherited defect of …

In order to investigate the risk of fetal loss in carriers of factor V Leiden who are family
members of probands with this mutation, we performed a retrospective cohort study …

Objectives: The factor V Leiden mutation is the most common genetic predisposition to
thrombosis. However, little is known concerning the reproductive outcome of mutation …

Results: The 64 homozygous women had in total 212 pregnancies, the 52 control women
had 118 pregnancies. In homozygous women 65% of pregnancies ended with delivery of a …

OBJECTIVE: We hypothesized that the thrombophilic G1691A factor V Leiden (FVL) gene
mutation was a common, significant, and treatable cause of sporadic and recurrent …

BACKGROUND AND OBJECTIVES: In this retrospective, single center, cohort study we
assessed the risk of pregnancy-related venous thromboembolism (VTE) in women …