While epigenetic modifications have emerged as attractive substrates to integrate
environmental changes into the determination of cell identity and function, specific signals …

Epigenetic modifications have become an emerging interface that links extrinsic signals to
alterations of gene expression that determine cell identity and function. However, direct …

Environmental factors and life experiences impinge on brain circuits triggering adaptive
changes. Epigenetic regulators contribute to this neuroadaptation by enhancing or …

To identify the role of the histone acetyltransferase (HAT) CREB-binding protein (CBP) in
neurons of the CA1 region of the hippocampus during memory formation, we examine the …

Although the brain functions of specific acetyltransferases such as the CREB-binding protein
(CBP) and p300 have been well documented using mutant transgenic mice models, studies …

The lysine acetyltransferases type 3 (KAT3) family members CBP and p300 are important
transcriptional co-activators, but their specific functions in adult post-mitotic neurons remain …

Chromatin modification is an important epigenetic mechanism underlying neuroplasticity.
Histone methylation and acetylation have both been shown to modulate gene expression …

Rubinstein-Taybi syndrome (RSTS) is an inheritable disease associated with mutations in
the gene encoding the CREB (cAMP response element-binding protein)-binding protein …

CREB (cyclic AMP response element binding protein) binding protein (CBP, CREBBP) is a
ubiquitously expressed transcription coactivator with intrinsic histone acetyltransferase …

The stabilization of learned information into long-term memories requires new gene
expression. CREB binding protein (CBP) is a coactivator of transcription that can be …