Deregulation of NF-κB and its upstream kinases in cancer

SC Sun, G Xiao - Cancer and Metastasis Reviews, 2003 - Springer
The transcription factor NF-κB is known for its function in regulating immune and
inflammatory responses. However, recent evidence suggests that NF-κB also plays a pivotal …

NF-κB, an active player in human cancers

Y Xia, S Shen, IM Verma - Cancer immunology research, 2014 - AACR
NF-κB comprises a family of five transcription factors that form distinct protein complexes,
which bind to consensus DNA sequences at promoter regions of responsive genes …

Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression

DS Basseres, AS Baldwin - Oncogene, 2006 - nature.com
Abundant data support a key role for the transcription factor nuclear factor-κB (NF-κB)
signaling pathway in controlling the initiation and progression of human cancer. NF-κB and …

NF‐κB as a potential molecular target for cancer therapy

CH Lee, YT Jeon, SH Kim, YS Song - Biofactors, 2007 - Wiley Online Library
Nuclear factor κB (NF‐κB), a transcription factor, plays an important role in carcinogenesis
as well as in the regulation of immune and inflammatory responses. NF‐κB induces the …

The NF-κB transcription factor pathway as a therapeutic target in cancer: methods for detection of NF-κB activity

C Mauro, F Zazzeroni, S Papa, C Bubici… - Inflammation and Cancer …, 2009 - Springer
NF-κB transcription factors marshal innate and adaptive immunity and inflammation. NF-κB
also counters programmed cell death (PCD) induced by the proinflammatory cytokine tumor …

Regulation if NF-κB Transcriptional Activity

L Vermeulen, W Vanden Berghe… - The Link Between …, 2006 - Springer
Nuclear factor κB (NF-κB) is regarded as a key regulator of inflammation; hence, several
inflammatory diseases result from deregulation of NF-κB signaling. There is, however, also …

Evidence for the involvement of the master transcription factor NF-κB in cancer initiation and progression

YR Puar, MK Shanmugam, L Fan, F Arfuso, G Sethi… - Biomedicines, 2018 - mdpi.com
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the
regulation of a large number of genes that are involved in important physiological …

Non-conventional functions for NF-κB members: the dark side of NF-κB

L Espinosa, P Margalef, A Bigas - Oncogene, 2015 - nature.com
NF-κB pathway exerts an essential function in the regulation of the immune response, which
has been the nucleus of numerous studies for the past 25 years. Both activation of the …

[HTML][HTML] NF-κB and cancer: a paradigm of Yin-Yang

G Xiao, J Fu - American journal of cancer research, 2011 - ncbi.nlm.nih.gov
Recent studies have clearly linked nuclear factor-kappaB (NF-κB), a transcription factor that
plays a central role in regulating immune and inflammatory responses, to tumor …

NF‐κB and cancer: Mechanisms and targets

M Karin - … Carcinogenesis: Published in cooperation with the …, 2006 - Wiley Online Library
In addition to being a central coordinator of immune responses, NF‐κB signaling also plays
a critical role in cancer development and progression and it may determine the response to …