With major advances in experimental techniques to track antigen-specific immune
responses many basic questions on the kinetics of virus-specific immunity in humans remain …

Does target cell depletion, innate immunity, or adaptive immunity play the dominant role in
controlling primary acute viral infections? Why do some individuals have higher peak virus …

Background Although a safe and effective yellow fever vaccine was developed more than 80
years ago, several issues regarding its use remain unclear. For example, what is the …

Vaccination is one of the most efficient public healthcare measures to fight infectious
diseases. Nevertheless, the immune mechanisms induced in vivo by vaccination are still …

By preventing infectious diseases, vaccines contribute substantially to public health.
Besides, they offer great opportunities to investigate human immune responses. This is …

Background Within-host models describe the dynamics of immune cells when encountering
a pathogen, and how these dynamics can lead to an individual-specific immune response …

In order to understand the integrated behavior of the immune system, there is no alternative
to mathematical modeling. In addition, the advent of experimental tools such as gene arrays …

Infection transmission is a complex and dynamic process, and is therefore difficult to assess.
Consequently, mathematical models are a useful tool to understand any leverage on this …

ABSTRACT A detailed characterization of the dynamics and breadth of the immune
response to an acute viral infection, as well as the determinants of recruitment to …

Vaccines represent a potent tool to prevent or contain infectious diseases with high
morbidity or mortality. However, despite their widespread use, we still have a limited …