CARD 14 gain‐of‐function mutations cause psoriasis in humans and mice. Together with
BCL 10 and the protease MALT 1, mutant CARD 14 forms a signaling node that mediates …

Introduction CARD11 is a lymphoid lineage-specific scaffold protein regulating the NF-κB
activation downstream of the antigen receptor signal pathway. Defective CARD11 function …

CARD9 is an essential adaptor protein in antifungal innate immunity mediated by C-type
lectin receptors. The activity of CARD9 is critically regulated by ubiquitination; however, the …

Genetic mutations of CARD14 (encoding CARMA2) are observed in psoriasis patients. Here
we showed that Card14 E138A/+ and Card14 ΔQ136/+ mice developed spontaneous …

Psoriasis (PS) is a common inflammatory and incurable skin disease affecting 2–3% of the
human population. Although genome-wide association studies implicate more than 60 loci …

BACKGROUND: Allergy, the most common disease of immune dysregulation, has a
substantial genetic component that is poorly understood. Although complete disruption of T …

The caspase recruitment domain–containing protein 9 (CARD9)–B-cell lymphoma/leukemia
10 (Bcl10) signaling axis is activated in myeloid cells during the innate immune response to …

In recent years, a number of proteins have been identified that contain a homotypic
interaction motif called the caspase recruitment domain (CARD). Most proteins containing a …

The scaffolding protein CARD11 is a critical mediator of antigen receptor signaling in
lymphocytes. Hypomorphic (partial loss-of-function) mutations in CARD11 are associated …

Caspase recruitment domain-containing protein 9 (CARD9) is a critical adaptor molecule
triggered by the interaction of C-type lectin receptors (CLRs) with carbohydrate motifs found …