Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS …

MGS Borba, FFA Val, VS Sampaio… - JAMA network …, 2020 - jamanetwork.com
Importance There is no specific antiviral therapy recommended for coronavirus disease
2019 (COVID-19). In vitro studies indicate that the antiviral effect of chloroquine diphosphate …

Chloroquine diphosphate in two different dosages as adjunctive therapy of hospitalized patients with severe respiratory syndrome in the context of coronavirus (SARS …

MG Silva Borba, FF Almeida Val, VS Sampaio… - MedRxiv, 2020 - medrxiv.org
Background There is no specific antiviral therapy recommended for the disease caused by
SARS-CoV-2 (COVID-19). Recent publications have drawn attention to the possible benefit …

An open-label randomized controlled trial evaluating the efficacy of chloroquine/hydroxychloroquine in severe COVID-19 patients

Á Réa-Neto, RS Bernardelli, BMD Câmara, FB Reese… - Scientific reports, 2021 - nature.com
Despite several studies designed to evaluate the efficacy of chloroquine and
hydroxychloroquine in the treatment of coronavirus disease 2019 (COVID-19), there is still …

Effect of hydroxychloroquine on clinical status at 14 days in hospitalized patients with COVID-19: a randomized clinical trial

WH Self, MW Semler, LM Leither, JD Casey, DC Angus… - Jama, 2020 - jamanetwork.com
Importance Data on the efficacy of hydroxychloroquine for the treatment of coronavirus
disease 2019 (COVID-19) are needed. Objective To determine whether hydroxychloroquine …

A pragmatic randomized controlled trial reports lack of efficacy of hydroxychloroquine on coronavirus disease 2019 viral kinetics

MN Lyngbakken, JE Berdal, A Eskesen, D Kvale… - Nature …, 2020 - nature.com
Here, we randomized 53 patients hospitalized with coronavirus disease 2019 (COVID-19) to
hydroxychloroquine therapy (at a dose of 400 mg twice daily for seven days) in addition to …

Treating COVID-19 with hydroxychloroquine (TEACH): a multicenter, double-blind randomized controlled trial in hospitalized patients

RJ Ulrich, AB Troxel, E Carmody… - Open forum …, 2020 - academic.oup.com
Background Effective therapies to combat coronavirus 2019 (COVID-19) are urgently
needed. Hydroxychloroquine (HCQ) has in vitro antiviral activity against severe acute …

A multicenter, randomized, open-label, controlled trial to evaluate the efficacy and tolerability of hydroxychloroquine and a retrospective study in adult patients with …

CP Chen, YC Lin, TC Chen, TY Tseng, HL Wong… - PloS one, 2020 - journals.plos.org
Objective In this study, we evaluated the efficacy of hydroxychloroquine (HCQ) against
coronavirus disease 2019 (COVID-19) via a randomized controlled trial (RCT) and a …

Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19

M Huang, M Li, F Xiao, P Pang, J Liang… - National Science …, 2020 - academic.oup.com
Effective therapies are urgently needed for the SARS-CoV-2 pandemic. Chloroquine has
been proved to have antiviral effect against coronavirus in vitro. In this study, we aimed to …

Effect of hydroxychloroquine in hospitalized patients with Covid-19

RECOVERY Collaborative Group - New England Journal of …, 2020 - Mass Medical Soc
Background Hydroxychloroquine and chloroquine have been proposed as treatments for
coronavirus disease 2019 (Covid-19) on the basis of in vitro activity and data from …

Hydroxychloroquine versus placebo in the treatment of non-hospitalised patients with COVID-19 (COPE–Coalition V): A double-blind, multicentre, randomised …

Á Avezum, GBF Oliveira, H Oliveira… - The Lancet Regional …, 2022 - thelancet.com
Summary Background Previous Randomised controlled trials (RCT) evaluating chloroquine
and hydroxychloroquine in non-hospitalised COVID-19 patients have found no significant …