Over the past decade, solid tumors have increasingly become recognized as discrete
'organs' that show a complexity that approaches and may even exceed that of normal …

The evolutionary path from tumor initiation to metastasis can only be fully understood by
considering cancer cells as part of a multi-species ecosystem within the tumor …

Abstract The AACR-NCI Conference “Systems Biology: Confronting the Complexity of
Cancer” took place from February 27 to March 2, 2011, in San Diego, CA. Several themes …

Tumours contain diverse cell types and inflammatory mediators within their
microenvironment, such as tissue-resident and peripherally recruited immune cells …

The transformation of normal cells into cancer cells and maintenance of the malignant state
and phenotypes are associated with genetic and epigenetic deregulations, altered cellular …

Cancer cells all share the feature of being immersed in a complex environment with altered
cell-cell/cell-extracellular element communication, physicochemical information, and tissue …

Given the role and relevance of the heterogeneity hallmark in cancer, a current need is to
advance the knowledge of the network dynamics building the complex architecture …

Network approaches are ubiquitous, from social and ecological systems up to complex
biological processes. In our recently published work we used the network framework for a …

Cancer is not just a lump of cells that divide, invade, and spread randomly, but rather a multi-
layered precisely tuned process that requires the participation of the whole organism. There …

A bottleneck that is hindering therapeutics innovation in cancers is the current lack of
integration of what we have learned in tumor biology as well as the tumor microenvironment …