Osteopetroses are rare human genetic disorders due to markedly decreased bone
resorption. To date, the only gene whose inactivation was known to be responsible for …

The osteopetroses are a heterogeneous group of bone remodeling disorders characterized
by an increase in bone density due to a defect in osteoclastic bone resorption. In humans …

Osteopetrosis is a metabolic bone disease inherited in a number of species including
human beings and characterized by a generalized increase in skeletal density detected …

Osteopetrosis is a rare skeletal condition characterized by skeletal sclerosis caused by
aberrant osteoclast-mediated bone resorption. Three clinically distinct forms of osteopetrosis …

Osteopetrosis is a metabolic bone disease characterized by excessive accumulation of
skeletal mass due to a reduction in bone resorption. The pathogenesis of osteopetrosis is …

Osteopetrosis is a metabolic bone disease characterized by a systemic increase in skeletal
mass. It results from a defect in the production or function of osteoclasts and is inherited in …

Human recessive osteopetrosis (ARO) represents a group of diseases in which, due to a
defect in osteoclasts, bone resorption is prevented. The deficit could arise either from failure …

Autosomal recessive osteopetrosis is a rare congenital disorder characterized by the
development of abnormally dense bones, acrocephaly, severe anemia …

Osteopetrosis is the result of mutations affecting osteoclast function. Careful analyses of
osteopetrosis have provided instrumental information on bone remodeling, including the …

Throughout life, bone tissue is in a constant state of turnover. This process of bone
remodeling is the result of a combination of sequential removal of bone tissue by osteoclasts …