Abstract Felix R, Hofstetter W, Cecchini MG. Recent developments in the understanding of
the pathophysiology of osteopetrosis. Eur J Endocrinol 1996; 134: 143–56. ISSN 0804 …

In order to investigate the ultrastructure of bone resorptive cells in the two types of adult
benign human osteopetrosis, iliac crest biopsies were obtained from 11 patients and 10 …

Osteopetrosis is a metabolic bone disease characterized by reduced bone resorption. From
experimental studies of various osteopetrotic mutations has emerged the hypothesis that …

Asymptomatic gene carriers and clinically affected ADO2 subjects have the same ClCN7
mutation. We examined osteoclastic bone resorption in vitro as well as osteoclast formation …

This review of the mechanism of osteopetrosis incriminates molecular defects in osteoclasts
as the cause of the imbalance between bone formation by osteoblasts and bone resorption …

Osteopetrosis (OPT) is a life-threatening disease characterized by increased bone mass
caused by diminished osteoclast function/differentiation. The autosomal recessive forms …

Progress has been made in recent years on the cell biology of the osteoclast and the
pathogenesis of congenital osteopetrosis. New information is critically evaluated and …

Osteopetrosis comprises a group of rare metabolic diseases of skeletal development that
are characterized by a generalized increase in skeletal mass resulting from reduced …

Osteopetrosis results from diminished osteoclast action. Defective skeletal resorption is
revealed by the persistence of primary spongiosa deposited during endochondral bone …

Abstract Purpose of Review The term osteopetrosis refers to a group of rare skeletal
diseases sharing the hallmark of a generalized increase in bone density owing to a defect in …