Malignant osteopetrosis is a rare congenital disorder of bone resorption, occurring in less
than 1 in 200 000 births. It is caused by the failure of osteoclasts to resorb immature bone …

Osteopetrosis manifests as failure of osteoclastic bone resorption. The cause of the disease
lies either in the hematopoietic lineage or in the bone marrow stromal microenvironment. It …

Although young mice homozygous for the osteopetrosis (op) mutation usually developed
prominent osteopetrosis, its severity was markedly reduced in aged op/op mice. This age …

Context: Autosomal dominant osteopetrosis (ADO) is a sclerosing bone disorder caused by
heterozygous mutations in the chloride channel 7 (ClCN7) gene. The clinical manifestations …

Dysfunction in or lack of osteoclasts result in osteopetrosis, a group of rare but often severe,
genetic disorders characterized by an increase in bone mass, skeletal malformations and …

Osteopetrosis is a rare genetic disease of bone resorption. It includes a variety of hereditary
skeletal disorders that have the main radiographic feature of increased bone density and …

AN ADULT with diffuse radiological osteosclerosis, enlarged corticalis, narrowed marrow
space, and associated multiple fractures was described as a new clinical entity for the first …

Osteopetrosis is a rare genetic disorder characterized by an increase of bone mass due to
defective osteoclast function. Patients typically displayed spontaneous fractures, anemia …

Skeletal dysplasias (SKD) with increased bone density form a discrete group of SKDs as per
the Nosology and Classification of Genetic Skeletal Disorders, 2010 Revision. This group …

Osteopetrosis is an inherited disorder characterized by reduced bone resorption. We here
report a rare case of osteopetrosis associated with rheumatoid arthritis. The patient was …