[HTML][HTML] Association Between Genetically Predicted Expression of TPMT and Azathioprine Adverse Events
A Davis, AL Dickson, LL Daniel, P Nepal… - Research …, 2023 - ncbi.nlm.nih.gov
Polymorphisms thiopurine-S-methyltransferase (TPMT) and nudix hydrolase 15 (NUDT15)
can increase the risk of azathioprine myelotoxicity, but little is known about other genetic …
can increase the risk of azathioprine myelotoxicity, but little is known about other genetic …
Predicted expression of genes involved in the thiopurine metabolic pathway and azathioprine discontinuation due to myelotoxicity
LL Daniel, AL Dickson, JT Zanussi… - Clinical and …, 2022 - Wiley Online Library
TPMT and NUDT15 variants explain less than 25% of azathioprine‐associated
myelotoxicity. There are 25 additional genes in the thiopurine pathway that could also …
myelotoxicity. There are 25 additional genes in the thiopurine pathway that could also …
Combining clinical and candidate gene data into a risk score for azathioprine-associated leukopenia in routine clinical practice
Leukopenia is a serious, frequent side effect associated with azathioprine use. Currently, we
use thiopurine methyltransferase (TPMT) testing to predict leukopenia in patients taking …
use thiopurine methyltransferase (TPMT) testing to predict leukopenia in patients taking …
TPMT and NUDT15 Variants Predict Discontinuation of Azathioprine for Myelotoxicity in Patients with Inflammatory Disease: Real‐World Clinical Results
AL Dickson, LL Daniel, J Zanussi… - Clinical …, 2022 - Wiley Online Library
Azathioprine is used frequently to treat several inflammatory conditions. However, treatment
is limited by adverse events—in particular, myelotoxicity. Thiopurine‐S‐methyltransferase …
is limited by adverse events—in particular, myelotoxicity. Thiopurine‐S‐methyltransferase …
Modeling the outcome of systematic TPMT genotyping or phenotyping before azathioprine prescription: a cost-effectiveness analysis
K Zarca, I Durand-Zaleski, MA Loriot… - Molecular Diagnosis & …, 2019 - Springer
Abstract Background Thiopurine S-methyltransferase (TPMT) testing, either by genotyping or
phenotyping, can reduce the incidence of adverse severe myelotoxicity episodes induced by …
phenotyping, can reduce the incidence of adverse severe myelotoxicity episodes induced by …
A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: the TARGET study
WG Newman, K Payne, K Tricker, SA Roberts… - …, 2011 - Taylor & Francis
Aim: To conduct a pragmatic, randomized controlled trial to assess whether thiopurine
methyltransferase (TPMT) genotyping prior to azathioprine reduces adverse drug reactions …
methyltransferase (TPMT) genotyping prior to azathioprine reduces adverse drug reactions …
[HTML][HTML] Azathioprine dose tailoring based on pharmacogenetic information: Insights of clinical implementation
X Díaz-Villamarín, E Fernández-Varón… - Biomedicine & …, 2023 - Elsevier
Azathioprine is commonly used as an immunosuppressive antimetabolite in the treatment of
acute lymphoblastic leukemia, autoimmune disorders (such as Crohn's disease and …
acute lymphoblastic leukemia, autoimmune disorders (such as Crohn's disease and …
[HTML][HTML] The cost-effectiveness of a pharmacogenetic test: a trial-based evaluation of TPMT genotyping for azathioprine
AJ Thompson, WG Newman, RA Elliott, SA Roberts… - Value in Health, 2014 - Elsevier
Background Thiopurine-methyl transferase (TPMT) testing prior to the prescription of
azathioprine in autoimmune diseases is one of the few examples of a pharmacogenetic test …
azathioprine in autoimmune diseases is one of the few examples of a pharmacogenetic test …
[HTML][HTML] Azathioprine therapy and TPMT and NUDT15 genotype
L Dean - Medical Genetics Summaries [Internet], 2020 - ncbi.nlm.nih.gov
Azathioprine (brand names Imuran, Azasan) is an immunosuppressant that belongs to the
drug class of thiopurines. It is used with other drugs to prevent kidney transplant rejection …
drug class of thiopurines. It is used with other drugs to prevent kidney transplant rejection …
Are patients with intermediate TPMT activity at increased risk of myelosuppression when taking thiopurine medications?
JE Higgs, K Payne, C Roberts, WG Newman - Pharmacogenomics, 2010 - Taylor & Francis
Thiopurine S-methyltransferase (TPMT) metabolizes thiopurine medications, including
azathioprine and 6-mercaptopurine. Absent TPMT activity (ie, in individuals homozygous for …
azathioprine and 6-mercaptopurine. Absent TPMT activity (ie, in individuals homozygous for …