Photoinduced arylative formal 4-endo-dig cyclization of propargyl alcohols/amines to access strained heterocycles

PV Reddy, A Nagireddy, JB Nanubolu, MS Reddy - Green Chemistry, 2024 - pubs.rsc.org
The development of green and sustainable approaches for the synthesis of small molecules
is always in demand. Oxetanes and azetidines are strained heterocycles that possess …

Access to 4‐Membered Heterocycles via Visible‐Light Triggered Intramolecular Cyclization from Alkynes: Bypassing Unfavorable 4‐endo‐dig Cyclization

A Sharma, A Choi, D Yim, H Kim… - Advanced Synthesis & …, 2024 - Wiley Online Library
We describe a catalyst, oxidant, and coupling‐reagent free strategy to access 4‐membered
heterocycles, representing a unique example of visible‐light triggered intramolecular …

Photomediated Spirocyclization of N-Benzyl Propiolamide with N-Iodosuccinimide for Access to Azaspiro[4.5]deca-6,9-diene-3,8-dione

M Yang, J Hua, H Wang, T Ma, C Liu… - The Journal of …, 2022 - ACS Publications
A metal-and oxidant-free route for affording azaspiro [4.5] deca-6, 9-diene-3, 8-dione via
photomediated iodinated spirocyclization of N-(4-methoxybenzyl) propiolamide has been …

Synthesis of azetidines via visible-light-mediated intermolecular [2+ 2] photocycloadditions

MR Becker, ER Wearing, CS Schindler - Nature Chemistry, 2020 - nature.com
Abstract Intermolecular [2+ 2] photocycloadditions represent a powerful method for the
synthesis of highly strained, four-membered rings. Although this approach is commonly …

Nitrogen‐Radical‐Triggered Trifunctionalizing ipso‐Spirocyclization of Unactivated Alkenes with Vinyl Azides: A Modular Access to Spiroaminal Frameworks

Z Qi, Z Zhang, L Yang, D Zhang, J Lu… - Advanced Synthesis …, 2021 - Wiley Online Library
We report an example of non‐dearomative trifunctionalizing ipso‐spirocyclization of
unactivated alkenes through photoredox‐catalyzed, nitrogen‐radical‐triggered cyclization …

Towards a General Access to 1‐Azaspirocyclic Systems via Photoinduced, Reductive Decarboxylative Radical Cyclizations

N Kiprova, M Desnoyers, R Narobe… - … A European Journal, 2024 - Wiley Online Library
A convenient and versatile approach to important 1‐azaspirocyclic systems relevant to
medicinal chemistry and natural products is reported herein. The main strategy relies on a …

Intramolecular ipso-Cyclization of N-Arylpropiolamides: A Novel and Straightforward Synthetic Approach for Azaspiro [4.5] decatrien-2-ones

E Vessally, M Babazadeh, K Didehban… - Current Organic …, 2018 - ingentaconnect.com
Background: Spiro [4.5] decenones are privileged structural motifs occurring in various
biologically active natural and unnatural compounds. Moreover, they are very important …

Synthesis of Benzoazepinone Derivatives via Photoredox Deaminative Radical Cascade Alkylation of 1, 7-Dienes and 1, 7-Enynes

WC de Souza, RN Lima, IS de Jesus, JTM Correia… - …, 2023 - thieme-connect.com
A deaminative alkyl radical cascade cyclization of 1, 7-dienes is described under visible-
light photocatalysis. This method delivers a family of benzoazepinones (benzazepinones) …

Photoinduced Temperature-Regulated Selective Carbene C–H Insertion for the Synthesis of Functionalized Spiro-β-lactones and-lactams

AR Samim Mondal, B Ghorai, DP Hari - Organic Letters, 2023 - ACS Publications
A temperature-regulated catalyst-free photoinduced selective carbene C–H insertion
strategy was realized to efficiently synthesize spiro-β-lactones and-lactams, which hold …

Visible-light-induced dearomatization via [2+ 2] cycloaddition or 1, 5-hydrogen atom transfer: divergent reaction pathways of transient diradicals

M Zhu, X Zhang, C Zheng, SL You - ACS Catalysis, 2020 - ACS Publications
Visible-light-induced dearomatization reaction via energy-transfer mechanism is an
emerging strategy for the synthesis of highly strained polycyclic molecules. Transient, high …