Interleukin-6 receptor inhibition in Covid-19—cooling the inflammatory soup

EJ Rubin, DL Longo, LR Baden - New England Journal of …, 2021 - Mass Medical Soc
Viruses cannot replicate by themselves. Instead, they rely on the host for almost all their
replicative functions. Similarly, many viruses are unable to cause damage without the host …

Interleukin-6 receptor antagonists in critically ill patients with Covid-19

Remap-Cap Investigators - New England Journal of Medicine, 2021 - Mass Medical Soc
Background The efficacy of interleukin-6 receptor antagonists in critically ill patients with
coronavirus disease 2019 (Covid-19) is unclear. Methods We evaluated tocilizumab and …

Role of interferon therapy in severe COVID-19: the COVIFERON randomized controlled trial

I Alavi Darazam, S Shokouhi, MA Pourhoseingholi… - Scientific reports, 2021 - nature.com
Abstract Type 1 Interferons (IFNs) have been associated with positive effects on
Coronaviruses. Previous studies point towards the superior potency of IFNβ compared to …

IL-6 inhibition in critically ill COVID-19 patients is associated with increased secondary infections

LM Kimmig, D Wu, M Gold, NN Pettit, D Pitrak… - Frontiers in …, 2020 - frontiersin.org
Background: Anti-inflammatory therapies such as IL-6 inhibition have been proposed for
COVID-19 in a vacuum of evidence-based treatment. However, abrogating the inflammatory …

Author Correction: Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages

M Merad, JC Martin - Nature Reviews. Immunology, 2020 - ncbi.nlm.nih.gov
In the originally published article, the imprecise wording of a sentence implied that IL-6
blockade had been approved by the FDA for treatment of COVID-19. This has now been …

The role of IL-6 in coronavirus, especially in COVID-19

X Wang, G Tang, Y Liu, L Zhang, B Chen… - Frontiers in …, 2022 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infects both people and
animals and may cause significant respiratory problems, including lung illness: Corona …

[HTML][HTML] Elevated interleukin‐6 is associated with severity of COVID‐19: a meta‐analysis

J Zhu, J Pang, P Ji, Z Zhong, H Li, B Li… - Journal of medical …, 2021 - ncbi.nlm.nih.gov
Coronavirus disease 2019 (COVID‐19) has spread rapidly around the world since its
emergence in humans last December. Previous studies suggested that numerous markers …

Interleukin-6 blockade for severe COVID-19

M Roumier, R Paule, M Groh, A Vallée, F Ackermann… - medrxiv, 2020 - medrxiv.org
In the context of COVID-19 pandemic and growing tensions worldwide regarding healthcare
facilities, there is an urgent need for effective treatments likely to reduce the crunch of ICU …

[HTML][HTML] Elevated interleukin‐6 and severe COVID‐19: a meta‐analysis

M Aziz, R Fatima, R Assaly - Journal of medical virology, 2020 - ncbi.nlm.nih.gov
To the Editor, We read with interest the study by Luo et al 1 that evaluates the efficacy of
tocilizumab (antibody against interleukin‐6 [IL‐6]) in patients with coronavirus disease 2019 …

A review of treatment of coronavirus disease 2019 (COVID-19): Therapeutic repurposing and unmet clinical needs

PL Chen, NY Lee, CT Cia, WC Ko… - Frontiers in …, 2020 - frontiersin.org
For the initial phase of pandemic of coronavirus disease 2019 (COVID-19), repurposing
drugs that in vitro inhibit severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) …