The role of IL-6 in coronavirus, especially in COVID-19

X Wang, G Tang, Y Liu, L Zhang, B Chen… - Frontiers in …, 2022 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infects both people and
animals and may cause significant respiratory problems, including lung illness: Corona …

Anti-IL6R role in treatment of COVID-19-related ARDS

FM Buonaguro, I Puzanov, PA Ascierto - Journal of translational medicine, 2020 - Springer
SARS-CoV-2 infection is not like the seasonal flu. While the range of symptoms for the two
viruses is similar, the fraction with severe disease appears to be different. For COVID-19 …

Interleukin-6 and severe COVID-19: a systematic review and meta-analysis

H Mojtabavi, A Saghazadeh, N Rezaei - European Cytokine Network, 2020 - Springer
Background Evidence links COVID-19 severity to hyper-inflammation. Treatment with
tocilizumab, a monoclonal antibody directed against the interleukin-6 (IL-6) receptor, was …

Efficacy of interferon alpha for the treatment of hospitalized patients with COVID-19: A meta-analysis

M Buchynskyi, I Kamyshna, K Lyubomirskaya… - Frontiers in …, 2023 - frontiersin.org
Introduction IFN-α intervention may block SARS-CoV-2 replication and normalize the
deregulated innate immunity of COVID-19. Aim This meta-analysis aimed to investigate the …

Decreased mortality in coronavirus disease 2019 patients treated with tocilizumab: a rapid systematic review and meta-analysis of observational studies

J Malgie, JW Schoones, BG Pijls - Clinical Infectious Diseases, 2021 - academic.oup.com
Background We systematically reviewed the literature to answer the following research
questions:(1) Does interleukin 6 (IL-6)(receptor) antagonist therapy reduce mortality in …

Drug treatments for covid-19: living systematic review and network meta-analysis

RAC Siemieniuk, JJ Bartoszko, D Zeraatkar, E Kum… - bmj, 2020 - bmj.com
Objective To compare the effects of treatments for coronavirus disease 2019 (covid-19).
Design Living systematic review and network meta-analysis. Data sources WHO covid-19 …

COVID-19 treatment: close to a cure? A rapid review of pharmacotherapies for the novel coronavirus (SARS-CoV-2)

Y Song, M Zhang, L Yin, K Wang, Y Zhou… - International journal of …, 2020 - Elsevier
Currently, there is no approved therapy for coronavirus disease 2019 (COVID-19). The
World Health Organization (WHO) therefore endorses supportive care only. However …

Old and re-purposed drugs for the treatment of COVID-19

SS Jean, PR Hsueh - Expert review of anti-infective therapy, 2020 - Taylor & Francis
Introduction: The coronavirus disease 2019 (COVID-19) caused by the novel severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has developed since December 2019. It …

Efficacy and safety of interferon β-1a in treatment of severe COVID-19: A randomized clinical trial

E Davoudi-Monfared, H Rahmani, H Khalili… - MedRxiv, 2020 - medrxiv.org
Objectives To the best of our knowledge, there is no published study regarding use of IFN β-
1a in the treatment of severe COVID-19. In this randomized clinical trial efficacy and safety of …

Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions

Y Jamilloux, T Henry, A Belot, S Viel, M Fauter… - Autoimmunity …, 2020 - Elsevier
The coronavirus disease-19 pandemic (COVID-19), which appeared in China in December
2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up …